The Ti5553 alloy (5Al-5Mo-5 V-3Cr-0.5Fe) has been in the last years widely used in the manufacturing of high responsibility components for landing gear of large aircrafts, such as Boeing 787 and Airbus A380. It presents high resistance to corrosion and fatigue, high tensile strength, and hardness, allowing to produce thinner and lighter components. The machining of the Ti5553 alloy presents difficulty, due to its low thermal conductivity and the fact that maintaining its mechanical properties at high temperatures. So it must be performed using high-performance cutting fluids and special cutting tools. Recently, research works related to the addition of nanoparticles to MQL fluids have been explored to improve the performance of the machining process of titanium alloys. This work presents an investigation on the performance of turning Ti5553 using PCD as the cutting tool, using spherical copper nanoparticles, carbon nanotubes, and a hybrid nanoparticle (spherical copper + carbon nanotubes) added to the cutting fluid by MQL technique. It was evaluated the PCD tool wear mechanisms, the machining forces, and the surface integrity of Ti5553 workpieces, using high cutting speeds in the finishing process conditions. The results indicate that the best performance was achieved with nanofluid with the addition of spherical copper in all aspects analyzed, mainly in tool life and machining forces, while the hybrid nanofluid showed lower performance, like the base MQL fluid.