Ni-catalyzed reductive cyanation of alkenyl tosylates and triflates

被引：0
|
作者：
Graham, Joshua M. [1 ]
Rousseaux, Sophie A. L. [1 ]
机构：
[1] Univ Toronto, Dept Chem, Davenport Res Labs, 80 St George St, Toronto, ON M5S 3H6, Canada
来源：
CHEMICAL COMMUNICATIONS | 2025年 / 61卷 / 05期
基金：
加拿大自然科学与工程研究理事会; 加拿大创新基金会;
关键词：
REAGENTS; BOND;
D O I：
10.1039/d4cc04972a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we disclose the nickel-catalyzed reductive cyanation of alkenyl tosylates and triflates. Both cyclic and acyclic alkenyl nitriles are produced in moderate to good yield using 2-(4-methoxyphenyl)-2-methylmalononitrile (MeO-MPMN), a novel transnitrilation, or nitrile transfer, reagent. A robustness screen was undertaken to demonstrate the functional group tolerance of this method.
引用
收藏
页码：893 / 896
页数：4
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