Single nucleotide polymorphisms of GYS2 gene and its association with milk production traits of dairy cows

被引：0
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作者：
Ye, Wen [1 ]
Chen, Ao [1 ]
Xu, Lingna [1 ]
Sun, Dongxiao [1 ,2 ]
Han, Bo [1 ]
机构：
[1] Department of Animal Genetics and Breeding, College of Animal Science and Technology, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, State Key
[2] Beijing Jingwa Agricultural Innovation Center, Beijing, China
来源：
Animal Biotechnology | 2024年 / 35卷 / 01期
关键词：
Glycogen synthase 2 (GYS2) encodes liver glycogen synthase; a rate limiting enzyme in glycogen metabolism. Our preliminary work suggested that GYS2 was a candidate gene affecting milk production traits by analyzing the liver proteome of dairy cows. Herein; this research identified single nucleotide polymorphisms (SNPs) of GYS2; analyzed their genetic effects on traits of dairy cattle; and speculated the pathogenic mechanism through functional prediction of key mutation sites. Seven SNPs were found by resequencing and the association analysis showed that these SNPs were significantly associated with 305-day milk yield; fat yield; protein yield or fat percentage (p-value ≤ 0.0488). Six SNPs among them formed two haplotype blocks and they were associated with 305-day milk yield; protein yield or fat percentage (p-value ≤ 0.0349). Furthermore; 5:g.88602007G > A and 5:g.88602026G > A were predicted to change the transcription factor binding sites (TFBSs); which might regulate the expression of GYS2. The missense mutation site; 5:g.88602535G; T; changed the secondary structure of mRNA and the secondary and tertiary structure of protein. In summary; the GYS2 was proved to have genetic effect on milk production traits; and its valuable seven SNPs; could provide more useful genetic information for molecular breeding of dairy cows. © 2024 The Author(s). Published by Informa UK Limited; trading as Taylor & Francis Group;
D O I：
10.1080/10495398.2024.2432966
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