Visible Light-Induced Three-Component Alkoxyalkylation of Alkenes with α-Halocarbonyls and Alcohols

被引：0
|
作者：
Chowdhury, Soumyadeep Roy [2 ]
Kim, Hun Young [1 ]
Oh, Kyungsoo [2 ]
机构：
[1] Chung Ang Univ, Dept Global Innovat Drugs, Seoul 06974, South Korea
[2] Chung Ang Univ, Ctr Metareceptome Res, Grad Sch Pharmaceut Sci, Seoul 06974, South Korea
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 23期
基金：
新加坡国家研究基金会;
关键词：
PHOTOREDOX CATALYSIS; CHAIN EXTENSION; KETONES; ANNULATION; CHEMISTRY; YLIDES;
D O I：
10.1021/acs.joc.4c02374
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A visible-light-induced three-component alkoxyalkylation of alkenes has been developed under the photocatalysis of fac-Ir(ppy)3. The alkene substrate scope included aryl and aliphatic alkenes as well as electron-rich and electron-deficient alkenes, allowing the facile coupling with a diverse array of alpha-halocarbonyl compounds. The redox potential-guided orchestration of radical processes with precision allows rapid access to highly functionalized products that are useful building blocks in organic synthesis.
引用
收藏
页码：17621 / 17634
页数：14
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