Advances in virus-host interaction research based on microfluidic platforms

被引:0
|
作者
Cheng Wang [1 ,2 ]
Ji Wang [2 ,3 ]
Dong Liu [1 ]
ZhiLing Zhang [2 ]
机构
[1] School of Life Sciences,Co-Innovation Center of Neuroregeneration,Nantong Laboratory of Development and Diseases,Nantong University
[2] College of Chemistry and Molecular Sciences,Wuhan University
[3] Centre for Immunology and
关键词
D O I
暂无
中图分类号
R373 [人体病毒学(致病病毒)];
学科分类号
摘要
Viral epidemics pose a serious threat to global public health,making it essential to explore virus-host interactions for uncovering the pathogenesis of viral diseases and developing effective antiviral strategies.Traditional in vitro cell infection models struggle to replicate physiological microenvironment,while animal infection models may encounter obstacles such as species gap,high-cost,and ethical issues.Additionally,potential heterogeneous infection outcomes are usually inaccessible by population-based experiments.Microfluidics,as an emerging interdisciplinary platform,has proven to be a powerful tool for inquiring virus-host interactions.In this review,conventional virological methods were introduced first and remarkable advantages of microfluidics in viral cell biology were highlighted.Next,the in-depth applications of microfluidics in analyzing heterogeneity of virus-host interplays,dynamic monitoring of events related to viral life cycle,and modeling of viral infectious diseases were fully elaborated from the perspective of single-cell chip,multi-cell culture chip and organ-on-a-chip (organ chip).Finally,the opportunities and challenges in developing robust microfluidic methods for virology were discussed.Overall,this review aims to provide an overview of microfluidic-based research on virus-host interaction and promote multidisciplinary collaborations for better understanding and responding to viral threats.
引用
收藏
页码:153 / 165
页数:13
相关论文
共 50 条
  • [41] Quantification of the virus-host interaction in human T lymphotropic virus I infection
    Becca Asquith
    Angelina J Mosley
    Adrian Heaps
    Yuetsu Tanaka
    Graham P Taylor
    Angela R McLean
    Charles RM Bangham
    Retrovirology, 2
  • [42] Virus-host interactions: from systems biology to translational research
    Peng, Xinxia
    Chan, Eric Y.
    Li, Yu
    Diamond, Deborah L.
    Korth, Marcus J.
    Katze, Michael G.
    CURRENT OPINION IN MICROBIOLOGY, 2009, 12 (04) : 432 - 438
  • [43] A Docking Based Approach to Analyze Interaction Surfaces of Virus-Host Protein-Protein Interactions
    Matsuzaki, Yuri
    Simm, Jaak
    Uchikoga, Nobuyuki
    Akiyama, Yutaka
    BIOPHYSICAL JOURNAL, 2017, 112 (03) : 451A - 452A
  • [44] VIRUS-HOST INTERACTIONS - INTRODUCTION
    CRAWFORD, LV
    PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1980, 210 (1180): : 319 - 320
  • [45] The chronicles of virus-host affairs
    Langat, Pinky
    Petrova, Velislava
    NATURE REVIEWS MICROBIOLOGY, 2015, 13 (08) : 460 - 460
  • [46] Virus-host warfare by PROTACs
    Walters, Kylie J.
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2024, 25 (09) : 675 - 675
  • [47] ChikvInt: a Chikungunya virus-host protein-protein interaction database
    Kusari, M.
    Dey, L.
    Mukhopadhyay, A.
    LETTERS IN APPLIED MICROBIOLOGY, 2022, 74 (06) : 992 - 1000
  • [48] Novel virus-host interactions
    Sourvinos, G.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2011, 41 : 57 - 58
  • [49] Revealing Virus-Host Interplay
    Krupovic, Mart
    Bamford, Dennis H.
    SCIENCE, 2011, 333 (6038) : 45 - 46
  • [50] THE NATURE OF VIRUS-HOST SPECIFICITY
    PUCK, TT
    SCIENCE, 1951, 114 (2974) : 685 - 685