Metabolism of NAD+ in nuclei of Saccharomyces cerevisiae during stimulation of its biosynthesis by nicotinamide

被引：0
|
作者：
Gulyamova, T.G. [1 ]
Ruzieva, D.M. [1 ]
Nasmetova, S.M. [1 ]
Shakirzyanova, M.R. [1 ]
Kerbalaeva, A.M. [1 ]
机构：
[1] Inst. of Microbiology, Uzbekistan Acad. of Sciences, ul. Abdully Kodiry 7B, Tashkent, 700128, Uzbekistan
来源：
Biokhimiya | 2001年 / 66卷 / 09期
关键词：
Biosynthesis; -; Coenzymes; Metabolism; Yeast;
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学科分类号：
摘要：
The activities of nuclear enzymes involved in NAD+ metabolism in Saccharomyces cerevisiae strain 913a-1 and its mutant 110 previously selected as an NAD+ producer were investigated. The presence of extracellular nicotinamide increased the total NAD+ pool in the cells and increased [3H]nicotinic acid incorporation; however, NAD+ concentration in isolated nuclei decreased slightly. The stimulating effect of nicotinamide on intracellular synthesis of NAD+ correlated with increases in ADP-ribosyl transferase, NAD+-pyrophosphorylase, and NAD+ase activities.
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页码：1202 / 1205
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