(2R,3R,4R,5S)-3,4,5-Trihydroxy-2-(2-hydroxyethyl)piperidinium chloride

被引：0

作者：

Koman, Marian ^{[1
]}

Szolcsányi, Peter ^{[2
]}

Graczab, Tibor ^{[2
]}

机构：

[1] Department of Inorganic Chemistry, Slovak Technical University, Radlinského 9, Bratislava,812 37, Slovakia

[2] Department of Organic Chemistry, Slovak Technical University, Radlinského 9, Bratislava,812 37, Slovakia

来源：

| 2000年 / International Union of Crystallography, 5 Abbey Road, Chester, CH1 2HU, United Kingdom卷 / 56期

关键词：

Chlorine compounds - Ion chromatography - Ion exchange - Palladium compounds;

D O I：

10.1107/S0108270100003231

中图分类号：

学科分类号：

摘要：

(2R,3R,4R,5S)-3,4,5-Trihydroxy-2-(2-hydroxyethyl)piperidinium chloride was prepared by palladium(II)-catalyzed aminocarbolation of (2S,3S,4R)-1-benzylamino-2,3-di-O-benzylhex-5-ene-2,3,4-triol with lactone-ring opening and deprotection. The (2R,3R,4R,5S)-3,4,5-Trihydroxy-2-(2-hydroxyethyl)piperidinium chloride compound was also prepared by hydrogenolysis of the benzylated diol with H2 on Pd/C at room temperature in EtOH containing a few drops of aqueous HCl. The crude product was purified by ion-exchange chromatography and recrystallized from methanol/tert-butyl methyl ether.

引用

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