Crystal structure of β-ketoacyl-acyl carrier protein synthase III: A key condensing enzyme in bacterial fatty acid biosynthesis

被引:0
|
作者
Qiu, Xiayang [1 ]
Janson, Cheryl A. [1 ]
Konstantinidis, Alex K. [1 ]
Nwagwu, Silas [1 ]
Silverman, Carol [1 ]
Smith, Ward W. [1 ]
Khandekar, Sanjay [1 ]
Lonsdale, John [1 ]
Abdel-Meguid, Sherin S. [1 ]
机构
[1] SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, United States
来源
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:36465 / 36471
相关论文
共 50 条
  • [21] Bacterial β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) as a Target for Novel Antibacterial Agents Design
    Lu, X. Y.
    Tang, J.
    Zhang, Z.
    Ding, K.
    CURRENT MEDICINAL CHEMISTRY, 2015, 22 (05) : 651 - 667
  • [22] Crystal structure of β-ketoacyl-acyl carrier protein synthase II from E-coli reveals the molecular architecture of condensing enzymes
    Huang, WJ
    Jia, J
    Edwards, P
    Dehesh, K
    Schneider, G
    Lindqvist, Y
    EMBO JOURNAL, 1998, 17 (05): : 1183 - 1191
  • [23] Crystal structure of a substrate complex of Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A
    Musayev, F
    Sachdeva, S
    Scarsdale, JN
    Reynolds, KA
    Wright, HT
    JOURNAL OF MOLECULAR BIOLOGY, 2005, 346 (05) : 1313 - 1321
  • [24] Structural comparison of Acinetobacter baumannii β-ketoacyl-acyl carrier protein reductases in fatty acid and aryl polyene biosynthesis
    Lee, Woo Cheol
    Choi, Sungjae
    Jang, Ahjin
    Son, Kkabi
    Kim, Yangmee
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [25] Synthesis of Potent Inhibitors of β-Ketoacyl-Acyl Carrier Protein Synthase III as Potential Antimicrobial Agents
    Liu, Yan
    Zhong, Wu
    Li, Rui-Juan
    Li, Song
    MOLECULES, 2012, 17 (05) : 4770 - 4781
  • [26] Structural comparison of Acinetobacter baumannii β-ketoacyl-acyl carrier protein reductases in fatty acid and aryl polyene biosynthesis
    Woo Cheol Lee
    Sungjae Choi
    Ahjin Jang
    Kkabi Son
    Yangmee Kim
    Scientific Reports, 11
  • [27] The 1.8 Å crystal structure and active-site architecture of β-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli
    Davies, C
    Heath, RJ
    White, SW
    Rock, CO
    STRUCTURE, 2000, 8 (02) : 185 - 195
  • [28] The crystal structure of β-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 Å resolution and its relationship to other condensing enzymes
    Moche, M
    Dehesh, K
    Edwards, P
    Lindqvist, Y
    JOURNAL OF MOLECULAR BIOLOGY, 2001, 305 (03) : 491 - 503
  • [29] Key residues responsible for acyl carrier protein and β-ketoacyl-acyl carrier protein reductase (FabG) interaction
    Zhang, YM
    Wu, BN
    Zheng, J
    Rock, CO
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (52) : 52935 - 52943
  • [30] Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH)
    Shang, Ruofeng
    Liang, Jianping
    Yi, Yunpeng
    Liu, Yu
    Wang, Jiatu
    MOLECULES, 2015, 20 (09): : 16127 - 16141