Technetium-99m diethyldithiocarbamate (DDC): Comparison with thallium-201 DDC as an agent for brain imaging

被引：0
|
作者：
Ballinger, J.R. [1 ]
Gerson, B. [1 ]
Gulenchyn, K.Y. [1 ]
机构：
[1] Division of Nuclear Medicine, Ottawa Civic Hospital, Ottawa, Ont. K1Y 4E9, Canada
来源：
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes | 1987年 / 38卷 / 08期
关键词：
BIOLOGICAL MATERIALS - Imaging Techniques - RADIOACTIVE MATERIALS - Tracers;
D O I：
10.1016/0883-2889(87)90136-5
中图分类号：
学科分类号：
摘要：
Technetium-99m diethyldithiocarbamate (**9**9**mTc-DDC) was prepared by reduction of left bracket **9**9**m Tc right bracket pertechnetate with formamidine sulfinic acid in the presence of DDC at alkaline pH, both from extemporaneous solutions and in a kit formulation. The properties of **9**9**mTc-DDC were compared in vitro and in vivo with those of **2**0**1Tl-DDC, an agent used for cerebral perfusion imaging (CPI). **9**9**mTc-DDC is a lipophilic complex but its oil/water partition coefficient is lower than that of **2**0**1Tl-DDC. **9**9**mTc-DDC also shows greater binding to plasma proteins.
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页码：665 / 668
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