Design of hypoxia-targeting radiopharmaceuticals: Selective uptake of copper-64 complexes in hypoxic cells in vitro

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Biosciences Dept., University of Kent, Canterbury, United Kingdom ^{[1
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Eur. J. Nucl. Med. Mol. Imaging | / 7卷 / 788-792期

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Number:; -; Acronym:; MRC; Sponsor: Medical Research Council; EPSRC; Sponsor: Engineering and Physical Sciences Research Council; BBSRC; Sponsor: Biotechnology and Biological Sciences Research Council;

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共 29 条

[21] Radiobiological effects of hypoxia-dependent uptake of 64Cu-ATSM: enhanced DNA damage and cytotoxicity in hypoxic cells
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[22] In vitro and in vivo evaluation of copper-radiolabeled hypoxia targeting agents in the EMT6 hypoxic tumor model.
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McCarthy, DW
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[23] Copper complexes as prospective anticancer agents: in vitro and in vivo evaluation, selective targeting of cancer cells by DNA damage and S phase arrest
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[24] Development of Copper-64, Cobalt-55 and Gallium-68 Labeled Radiopharmaceuticals Targeting Neurotensin Receptor-1 for Cancer Diagnostic and Therapeutic Applications: Adjusting In Vivo Distribution using Multi-Amine Macrocycles
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JOURNAL OF NUCLEAR MEDICINE, 2024, 65
[25] Small interfering RNA targeting HIF-1α reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro
Staab, Adrian
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Said, Harun M.
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[26] PET imaging using a Copper-64 labeled TREM2 antibody with blood-brain barrier transport vehicle facilitates selective assessment of tumor associated immune cells in glioblastoma mice
Haertel, M.
Schaefer, R.
Park, H.
Hoermann, L.
Schlepckow, K.
Haass, C.
Lewcock, J. W.
Monroe, K. M.
Albert, N. L.
von Baumgarten, L.
Ziegler, S.
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Brendel, M.
Bartos, L. M.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2024, 51 : S400 - S400
[27] Design and structure analysis of artificial metalloproteins:: Selective coordination of his64 to copper complexes with square-planar structure in the apo-myoglobin scaffold
Abe, Satoshi
Ueno, Takafumi
Reddy, Pattubala A. N.
Okazaki, Seiji
Hikage, Tatsuo
Suzuki, Atsuo
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[28] In Vitro Targeting and Selective Killing of T47D Breast Cancer Cells by Purpurin and 5-Fluorouracil Anchored to Magnetic CNTs: Nitrene-Based Functionalization versus Uptake, Cytotoxicity, and Intracellular Fate
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[29] Small interfering RNA targeting HIF-1α reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitroHypoxia-inducible-Factor-1α-Small-Interfering-RNA inhibiert die hypoxische Akkumulation von HIF-1 α und erhöht die Strahlensensitivität von HT-1080-Fibrosarkomzellen in vitro
Adrian Staab
Markus Fleischer
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Harun M. Said
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Herrmann Einsele
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Strahlentherapie und Onkologie, 2011, 187 (4)

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