Modified method of synthesis of N-substituted dithioesters of amino acids and peptides in the Pinner reaction

被引：0
|
作者：
Neugebauer, Witold [1 ,2 ]
Pinet, Eric [1 ]
Kim, Munsok [1 ]
Carey, Paul R. [1 ]
机构：
[1] Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ont. K1A 0R6, Canada
[2] Département de Pharmacologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Que. J1H 5N4, Canada
来源：
Canadian Journal of Chemistry | 1996年 / 74卷 / 03期
关键词：
Addition reactions - Alcohols - Amino acids - Chemical activation - Derivatives - Hydrofluoric acid - Isotopes - Raman spectroscopy - Synthesis (chemical);
D O I：
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摘要：
An improved method for the synthesis of dithioesters of amino acids and peptides has been developed. The syntheses have been carried out from the nitriles. The addition of thiol to the nitrile derivative in the Pinner step of dithioester synthesis was activated with hydrogen fluoride. A few examples of dithioester synthesis using liquid HF are described. Some novel dithioesters, which are model compounds for resonance Raman spectroscopic studies of dithioacylpapain intermediates, are described.
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页码：341 / 343
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