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Hunan Univ, Collaborat Innovat Ctr Chem & Mol Med, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Coll Life Sci,Mol Sci & Bio, Changsha 410082, Hunan, Peoples R China Hunan Univ, Collaborat Innovat Ctr Chem & Mol Med, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Coll Life Sci,Mol Sci & Bio, Changsha 410082, Hunan, Peoples R China