Model-based real-time optimization in continuous pharmaceutical manufacturing

被引：0

作者：

Damiri, Hazem ^{[1
]}

Steinberger, Martin ^{[1
]}

Kuchler, Lisa ^{[2
]}

Azimi, Atabak ^{[1
,2
]}

Martinuzzi, Stefano ^{[2
,3
]}

Sagmeister, Peter ^{[2
,3
]}

Williams, Jason D. ^{[2
,3
]}

Koch, Stefan ^{[1
]}

Tranninger, Markus ^{[1
]}

Rehrl, Jakob ^{[2
]}

Celikovic, Selma ^{[1
,2
]}

Sacher, Stephan ^{[2
]}

Kappe, C. Oliver ^{[2
,3
]}

Horn, Martin ^{[1
]}

机构：

[1] Graz Univ Technol, Inst Automat & Control, Inffeldgasse 21-B, A-8010 Graz, Austria

[2] Res Ctr Pharmaceut Engn GmbH, Inffeldgasse 13, A-8010 Graz, Austria

[3] Karl Franzens Univ Graz, Inst Chem, Heinrichstr 28, A-8010 Graz, Austria

来源：

COMPUTERS & CHEMICAL ENGINEERING | 2025年 / 192卷

关键词：

Real-time optimization; Continuous pharmaceutical manufacturing; Direct compaction; Continuous synthesis; SURROGATE-BASED OPTIMIZATION; INGREDIENT;

D O I：

10.1016/j.compchemeng.2024.108915

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

In this work, real-time optimization (RTO) schemes are proposed and applied on a continuous pharmaceutical manufacturing process which consists of three units: synthesis unit, hot melt extrusion unit and direct compaction line. The developed RTO strategies calculate the operating conditions by optimizing the considered objective functions while satisfying the specific constraints. Moreover, the RTO schemes can cope with intentional changes in the process and unintentional changes such as disturbances. Results from simulations and experiments are presented in this work. An advantageous performance is achieved when using the developed schemes.

引用

页数：16

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