Model-based real-time optimization in continuous pharmaceutical manufacturing

被引：0

作者：

Damiri, Hazem ^{[1
]}

Steinberger, Martin ^{[1
]}

Kuchler, Lisa ^{[2
]}

Azimi, Atabak ^{[1
,2
]}

Martinuzzi, Stefano ^{[2
,3
]}

Sagmeister, Peter ^{[2
,3
]}

Williams, Jason D. ^{[2
,3
]}

Koch, Stefan ^{[1
]}

Tranninger, Markus ^{[1
]}

Rehrl, Jakob ^{[2
]}

Celikovic, Selma ^{[1
,2
]}

Sacher, Stephan ^{[2
]}

Kappe, C. Oliver ^{[2
,3
]}

Horn, Martin ^{[1
]}

机构：

[1] Graz Univ Technol, Inst Automat & Control, Inffeldgasse 21-B, A-8010 Graz, Austria

[2] Res Ctr Pharmaceut Engn GmbH, Inffeldgasse 13, A-8010 Graz, Austria

[3] Karl Franzens Univ Graz, Inst Chem, Heinrichstr 28, A-8010 Graz, Austria

来源：

COMPUTERS & CHEMICAL ENGINEERING | 2025年 / 192卷

关键词：

Real-time optimization; Continuous pharmaceutical manufacturing; Direct compaction; Continuous synthesis; SURROGATE-BASED OPTIMIZATION; INGREDIENT;

D O I：

10.1016/j.compchemeng.2024.108915

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

In this work, real-time optimization (RTO) schemes are proposed and applied on a continuous pharmaceutical manufacturing process which consists of three units: synthesis unit, hot melt extrusion unit and direct compaction line. The developed RTO strategies calculate the operating conditions by optimizing the considered objective functions while satisfying the specific constraints. Moreover, the RTO schemes can cope with intentional changes in the process and unintentional changes such as disturbances. Results from simulations and experiments are presented in this work. An advantageous performance is achieved when using the developed schemes.

引用

页数：16

共 50 条

[1] Model-Based Reinforcement Learning in Continuous Environments Using Real-Time Constrained Optimization
Andersson, Olov
Heintz, Fredrik
Doherty, Patrick
PROCEEDINGS OF THE TWENTY-NINTH AAAI CONFERENCE ON ARTIFICIAL INTELLIGENCE, 2015, : 2497 - 2503
[2] Model-based real-time optimization of automotive gasoline blending operations
Singh, A
Forbes, JF
Vermeer, PJ
Woo, SS
JOURNAL OF PROCESS CONTROL, 2000, 10 (01) : 43 - 58
[3] Real-Time Model-Based Fault Detection of Continuous Glucose Sensor Measurements
Turksoy, Kamuran
Roy, Anirban
Cinar, Ali
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2017, 64 (07) : 1437 - 1445
[4] A real-time model-based virtual phone
Huang, CF
Hung, CS
Lin, IC
Yang, TJ
Ouhyoung, M
PROCEEDINGS OF THE 6TH INTERNATIONAL CONFERENCE ON COMPUTER AIDED DESIGN & COMPUTER GRAPHICS, 1999, : 921 - 925
[5] Model-based real-time head tracking
Ström, J
EURASIP JOURNAL ON APPLIED SIGNAL PROCESSING, 2002, 2002 (10) : 1039 - 1052
[6] Model-based Design for Real-time Software
Li, Yan
Zhang Hong-Jun
INTERNATIONAL JOURNAL OF COMPUTER SCIENCE AND NETWORK SECURITY, 2008, 8 (08): : 91 - 95
[7] Model-Based Design of Real-Time Systems
Thiele, Lothar
2014 26TH EUROMICRO CONFERENCE ON REAL-TIME SYSTEMS (ECRTS 2014), 2014, : XVI - XVI
[8] Model-Based Real-Time Head Tracking
Jacob Ström
EURASIP Journal on Advances in Signal Processing, 2002
[9] Model-Based Implementation of Real-Time Systems
Sacha, Krzysztof
COMPUTER SAFETY, RELIABILITY, AND SECURITY, PROCEEDINGS, 2008, 5219 : 332 - 345
[10] Distributed real-time model-based diagnosis
Chung, SH
Barrett, A
2003 IEEE AEROSPACE CONFERENCE PROCEEDINGS, VOLS 1-8, 2003, : 349 - 355

← 1 2 3 4 5 →