Retrospective Dosimetric Comparison of HDR Interventional Radiotherapy (Brachytherapy) Versus Planning with VMAT and Electron Beam Therapy for Non-Melanoma Skin Cancer Treatment

被引：1

作者：

Placidi, Elisa ^{[1
]}

Fionda, Bruno ^{[2
]}

Rosa, Enrico ^{[1
,3
]}

Lancellotta, Valentina ^{[2
]}

Napolitano, Antonio ^{[4
]}

De Angeli, Martina ^{[2
]}

Ciasca, Gabriele ^{[5
]}

Pastore, Francesco ^{[6
]}

Gambacorta, Maria Antonietta ^{[6
,7
]}

Tagliaferri, Luca ^{[2
,7
]}

De Spirito, Marco ^{[1
,5
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Diagnost Immagini & Radioterapia Onco, UOC Fis Sci Vita, I-00168 Rome, Italy

[2] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Diagnost Immagini & Radioterapia Onco, UOC Degenze Radioterapia Oncolog, I-00168 Rome, Italy

[3] eCampus Univ, Dept Theoret & Appl Sci, I-22060 Novedrate, Italy

[4] Bambino Gesu Pediat Hosp, Med Phys Unit, I-00165 Rome, Italy

[5] Univ Cattolica Sacro Cuore, Dipartimento Neurosci, Sez Fis, I-00168 Rome, Italy

[6] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Diagnost Immagini & Radioterapia Onco, UOC Serv Radioterapia Oncolog, I-00168 Rome, Italy

[7] Univ Cattolica Sacro Cuore, Dipartimento Sci Radiolog & Ematolog, I-00168 Rome, Italy

来源：

APPLIED SCIENCES-BASEL | 2024年 / 14卷 / 22期

关键词：

brachytherapy; interventional radiotherapy; dosimetric comparison; non-melanoma skin cancer treatment; VMAT; electron therapy; MOLD BRACHYTHERAPY; RADIATION; HEAD;

D O I：

10.3390/app142210669

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study compares dosimetric outcomes of high-dose-rate (HDR) interventional radiotherapy (IRT) using Iridium-192, Volumetric Modulated Arc Therapy (VMAT), and electron beam therapy for non-melanoma skin cancer (NMSC). A retrospective analysis of 25 patients showed that IRT provided a significantly higher mean dose to the clinical target volume (CTV) compared to VMAT and electron beam therapy. IRT and VMAT had comparable V95%CTV coverage, whilst electron therapy was less feasible for large CTVs. IRT delivered higher surface doses while minimizing deep tissue exposure compared to partial arc VMAT. Our findings support IRT for personalized and effective NMSC treatment.

引用

页数：8

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