A highly sensitive spectrofluorometric method for the Determination of a new antidepressant drug, reboxetine, in tablets

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作者：
Önal, Armaǧan [1 ]
机构：
[1] Istanbul University, Faculty of Pharmacy, Department of Analytical Chemistry, 34116, Beyazit, Istanbul, Turkey
来源：
Journal of AOAC International | 2006年 / 89卷 / 04期
关键词：
A highly sensitive; selective; and rapid spectrofluorometric method has been developed for the determination of reboxetine (REB) in tablets. The method is based on derivatization with 7-chloro-4-nitrobenzofurazan. The product showed an absorption maximum at 476 nm and a fluorescence emission peak at 533 nm in ethyl acetate. The optimum conditions of the reaction were investigated; and it was found that the reaction proceeded quantitatively at pH 8.5; 70°C in 5 min. The calibration graph is rectilinear over the range of 0.02-0.40 μg/mL. The relative standard deviation values for intraday and interday precision were 0.40-0.93 and 0.54-1.37%; respectively. The proposed method was applied to the assay of REB in tablets. Mean recovery of REB from the tablets ranged between 99.91-100.20%. The results were compared statistically with those obtained by a method reported in the literature. The method is sensitive; simple; and selective; and can be used for routine quality control analysis;
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页码：972 / 975
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