Aqueous-phase synthesis of cationic hydrogel nanoparticles with antibacterial properties

被引:0
|
作者
Yamauchi, Noriko [1 ]
Sue, Yuka [1 ]
Nagai, Tomoya [1 ]
Hakozaki, Shuntaro [2 ,3 ]
Saito, Takeru [2 ,4 ]
Sogame, Yoichiro [2 ]
Kobayashi, Yoshio [1 ]
机构
[1] Ibaraki Univ, Fac Appl Sci & Engn, Domain Mat Sci & Engn, 4-12-1,Naka narusawa cho, Hitachi, Ibaraki 3168511, Japan
[2] Natl Inst Technol, Fukushima Coll, Dept Appl Chem & Biochem, Nagao 30, Iwaki, Fukushima 9708034, Japan
[3] Fukushima Univ, Fac Symbiot Syst Sci, 1 Kanayagawa, Fukushima 9601296, Japan
[4] Univ Tsukuba, Coll Agri Biol Resource Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan
关键词
Hydrogel; Nanoparticle; Quaternary ammonium cation; Hydrophobic monomer; Dispersion stability; Antibacterial; PARTICLES; STYRENE; CORE;
D O I
10.1016/j.colsurfa.2024.135737
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Antibacterial hydrogel nanoparticles are expected to be used in many biomedical applications, such as drug delivery and the development of antibacterial materials. In this study, we developed a synthesis for hydrogel nanoparticles that are dispersible in liquid media and have antibacterial properties. The particles were synthesized by copolymerizing a hydrophilic monomer (2-hydroxyethyl methacrylate), a cationic monomer containing a quaternary ammonium cation (trimethylaminoethyl methacrylate chloride), and a crosslinker (ethylene glycol dimethacrylate) in an aqueous solution with a cationic polymerization initiator (2,2 '-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride) to form a hydrogel. A hydrophobic monomer (methyl methacrylate) was then added and the polymerization was continued. The number average particle diameter by scanning electron microscopy was 122 nm, and the hydrodynamic diameter by dynamic light scattering measurement in water was about 380 nm, suggesting swelling of the particles by water. Furthermore, water was able to penetrate the solidified dry powder, confirming the hydrophilic properties of the particles. The zeta potential of the particles was about +40 mV, and bovine serum albumin, which generally has a high adsorption to positively charged substances, was adsorbed in large amounts to the particle surface, indicating that the particles had sufficient cationicity. The particles maintained stable dispersions even in liquid media with high ionic strength and containing impurities, which is important for nanoparticles used in medical and hygiene applications. The antibacterial activity of the particles was evaluated by incubation with Klebsiella pneumoniae, a Gram-negative bacterium. Almost no K. pneumoniae remained present in the supernatant after incubation, demonstrating the antibacterial properties of the particles.
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页数:8
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