Research progress in detection technology of DNA adducts derived from aldehydes

Formaldehyde, acetaldehyde, acrolein and crotonaldehyde exist widely in environmental pollutants and cigarette smoke also contains trace amounts of these aldehyde compounds. They can cause damage by attacking nucleophilic groups in the body directly. A covalent bond can be formed with DNA molecule to form DNA adducts. The formation of DNA adducts is a form of damage of DNA, which can change genetic information in the process of DNA replication. This paper reviewed six typical DNA adducts derived from aldehydes in organism and their research methods and progress of using aldehydes-DNA adducts as biomarkers in cigarette smoke exposure. Simultaneous quantitative analysis of multiple DNA adducts for cigarette smoke and its future development were also discussed. ©, 2015, State Tobacco Monopoly Bureau and China Tobacco Society. All right reserved.