Nanoparticles bestow beneficial impacts on plants, specifically in increasing photosynthetic capacity and germination rate, pesticide delivery, managing pathogenicity and enhancing nutrient supply. The nanoparticles produced from the medicinal plant extracts are identified as an exceptional applicant in nanomedicine, cosmetics, and agricul-ture for the treatment of diseases as antimicrobial, antioxidant and anticancer agents, etc. Plant extracts actually have bioactive metabolites that provide therapeutic potential against a variety of diseases. Herein, we review the production of bioactive compounds from leaves, roots, seeds, flowers and stems. We further summarize the different methods for obtaining plant extracts and the green technologies for the synthesis of nanoparticles of plant derived bioactive compounds. Biotechnological aspects of these synthesized na-noparticles are also added here as highlights of this review. Overall, plant derived nano-particles provide an alternative to conventional approaches for drug delivery as well and present exciting opportunities for future research on novel areas. We explore patent applications for novel plant-derived nanoparticle technologies, highlighting their potential in various fields. © 2025 Bentham Science Publishers.