Synthesis and antibacterial activity of acrylpimaric acid and its thiadiazole derivatives

被引：0

作者：

Li, Jian ^{[1
]}

Rao, Xiao-Ping ^{[2
]}

Song, Zhan-Qian ^{[2
]}

Xiao, Guo-Min ^{[1
]}

Shang, Shi-Bin ^{[2
]}

机构：

[1] School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China

[2] Institute of Chemical Industry of Forest Products, CAF, National Engineering Lab. for Biomass Chemical Utilization, Jiangsu Province, Nanjing 210042, China

来源：

Chemistry and Industry of Forest Products | 2014年 / 34卷 / 03期

关键词：

Anti-bacterial activity - Diels-Alder addition - Gram-negative bacteria - Gram-positive bacterium - Rosin - Synthesized derivatives - Thiadiazoles;

D O I：

10.3969/j.issn.0253-2417.2014.03.010

中图分类号：

学科分类号：

摘要：

Acrylpimaric acid was prepared from rosin through Diels-Alder addition reaction, and then a series of thiadiazole derivatives from acrylpimaric acid were synthesized. Acrylpimaric Acid and its thiadiazole structures were characterized by IR, 1H NMR, MS, and elemental analysis. The antibacterial activities of these newly synthesized derivatives against Gram-negative bacteria and Gram-positive bacteria were also investigated. The results indicated that these compounds displayed extensive anti-bacterial activity against Gram-negative bacteria and gram-positive bacteria. Especially, compound 5f exhibited excellent antibacterial activity against Escherichia coli than bromogeramine. Compared with bromo-geramine (128 mg/L), compound 5f (64 mg/L) possessed a lower MIC value.

引用

页码：55 / 59

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