Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet-induced obese mice

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[1] [1,Kim, Hyunsook
[2] Bartley, Glenn E.
[3] Young, Scott A.
[4] Seo, Kun-Ho
[5] Yokoyama, Wallace
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Kim, H. (hyskim@ucdavis.edu) | 1600年 / American Chemical Society卷 / 61期
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The effect of hydroxypropyl methylcellulose (HPMC) on hepatic gene expression was analyzed by exon microarray and real-time PCR from livers of diet-induced obese (DIO) mice fed a high-fat (HF) diet supplemented with either 6% HPMC or 6% microcrystalline cellulose (MCC). HPMC-fed mice exhibited significantly reduced body weight gain (55% lower compared to MCC); liver weight (13%); plasma LDL-cholesterol concentration (45%); and HF diet-increased intestinal permeability (48%). HPMC significantly reduced areas under the curve for 2 h insulin and glucose responses; indicating enhanced insulin sensitivity and glucose metabolism. HPMC up-regulated hepatic genes related to fatty acid oxidation; cholesterol and bile acid synthesis; and cellular activation of glucocorticoid (bile acid recycling) and down-regulated genes related to oxidative stress; triglyceride synthesis; and polyunsaturated fatty acid elongation. In conclusion; HPMC consumption ameliorates the effects of a HF diet on intestinal permeability; insulin resistance; hepatic lipid accumulation; glucocorticoid-related bile acid recycling; oxidative stress; and weight gain in DIO mice. © 2013 American Chemical Society;
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