Semiaromatic Polyester-Ethers with Tunable Degradation Profiles

被引:1
|
作者
Judge, Nicola G. [1 ]
Segal, Maddison I. [2 ]
Silzer, Robert O. [1 ]
Dziewior, Courtney S. [1 ]
Chan, Yin Mei [1 ]
Grovogel, Sawyer J. [1 ]
Becker, Matthew L. [1 ,2 ,3 ,4 ]
机构
[1] Duke Univ, Dept Chem, Durham, NC 27708 USA
[2] Duke Univ, Thomas Lord Dept Mech Engn & Mat Sci, Durham, NC 27708 USA
[3] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[4] Duke Univ, Dept Orthopaed Surg, Durham, NC 27708 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
HYDROLYTIC DEGRADATION; SCAFFOLD DEGRADATION;
D O I
10.1021/acsmacrolett.4c00617
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Poly(epsilon-caprolactone) (PCL) is a widely utilized polymer within the biomedical field; however, one of its limitations is the multi-year long degradation profile. Herein, we report a semiaromatic polyester-ether (SAEE) PCL copolymer using a salicylic acid-based monomer which can disrupt the semicrystalline nature of the bulk material. The molar percentage of incorporation correlated to a linear decrease in melting and crystallization temperature, until a totally amorphous solid was seen at 37 mol %. Alongside this, mechanical analysis elucidated a softer, more extensible material with E ' decreasing from 292 to 222 to 43.8 MPa for PCL to 10 to 22 mol % SAEE, respectively. Accelerated basic degradation studies (2 M NaOH) exhibited total mass loss after 16 weeks for 6 mol % compared to only 38% mass loss for PCL over the same period. Overall, by varying the SAEE mol %, we show the ability to finely tune the thermal, mechanical, and degradation profiles of PCL copolymers while maintaining an advantageous biological profile.
引用
收藏
页码:1531 / 1538
页数:8
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