New Antimicrobial Materials Based on Plasticized Polyvinyl Chloride for Urinary Catheters: Preparation and Testing

被引:0
|
作者
Deleanu, Iuliana Mihaela [1 ]
Grosu, Elena [2 ]
Ficai, Anton [1 ,3 ,4 ]
Ditu, Lia Mara [5 ,6 ]
Motelica, Ludmila [1 ,3 ,4 ]
Oprea, Ovidiu-Cristian [1 ,3 ,4 ]
Pircalabioru, Gratiela Gradisteanu [4 ,6 ]
Sonmez, Maria [7 ]
Busuioc, Cristina [1 ]
Ciocoiu, Robert [2 ]
Antoniac, Vasile Iulian [2 ,4 ]
机构
[1] Natl Univ Sci & Technol POLITEHN Bucharest, Fac Chem Engn & Biotechnol, 1-7 Gh Polizu, Bucharest 011061, Romania
[2] Natl Univ Sci & Technol POLITEHN Bucharest, Fac Mat Sci & Engn, 313 Splaiul Independentei St, Bucharest 060042, Romania
[3] Natl Univ Sci & Technol POLITEHN Bucharest, Natl Ctr Micro & Nanomat, Splaiul Independentei 313, Bucharest 060042, Romania
[4] Acad Romanian Scientists, 3 Ilfov St, Bucharest 050044, Romania
[5] Univ Bucharest, Fac Biol, 1-3 Intr Portocalelor St, Bucharest 060101, Romania
[6] Univ Bucharest, Res Inst, 90 Sos Panduri, Bucharest 050663, Romania
[7] Natl Res & Dev Inst Text & Leather, Leather & Footwear Inst, 93 Ion Minulescu St, Bucharest 031215, Romania
关键词
urinary tract infections; silver nanoparticles; plasticizer; antimicrobial material; polyvinyl chloride; medical applications; POLY(VINYL CHLORIDE); SILVER NANOPARTICLES; TRACT-INFECTIONS; PVC; ANTIBACTERIAL; OIL; COATINGS;
D O I
10.3390/polym16213028
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Given the constant increased number of nosocomial infections in hospitals, especially associated with prolonged usage of inserted medical devices, our work aims to ameliorate clinical experience and promote faster healing of patients undergoing urinary catheterization by improving the properties of medical devices materials. Within this research, nine different composites were prepared based on polyvinyl chloride, using three different plasticizers (di-(2-ethylhexyl) phthalate, Proviplast 2646, and Proviplast 2755), and two different antimicrobial additives containing silver nanoparticles. The prepared materials were analyzed, and their physicochemical properties were determined: water absorption, relative density, plasticizer migration, hydrophobicity/hydrophilicity by contact angle measurement, Shore A hardness, tensile strength, and elongation at break. Structure and morphology were also investigated by means of FTIR, SEM, and EDX analyses, and thermal (TG-DSC) and biological properties were evaluated. The most important aspects of obtained results are showing that plasticizer migration was significantly reduced (to almost zero) and that the usage of antimicrobial additives improved the materials' biocompatibility. Thus, based on the concluded favorable properties, the obtained materials can be further used for catheter development. Pressure-flow studies for different sizes and configurations are the next steps toward advanced in vivo and clinical trials.
引用
收藏
页数:29
相关论文
共 50 条
  • [21] Comparative activity of silver-based antimicrobial composites for urinary catheters
    Thokala, Nikhil
    Kealey, Carmel
    Kennedy, James
    Brady, Damien B.
    Farrell, Joseph
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2018, 52 (02) : 166 - 171
  • [22] Preparation and Characterization of Composites Materials with Rubber Matrix and with Polyvinyl Chloride Addition (PVC)
    Dobrota, Dan
    Petrescu, Valentin
    Dimulescu, Cristinel Sabin
    Oleksik, Mihaela
    POLYMERS, 2020, 12 (09) : 1 - 27
  • [23] Performance assessment of polyvinyl chloride films plasticized with Citrullus lanatus seed oil based novel plasticizer
    Patil, Sangram Shamrao
    Jena, Hara Mohan
    POLYMER TESTING, 2021, 101
  • [24] STORAGE OF PLATELETS IN A NEW PLASTIC CONTAINER - POLYVINYL-CHLORIDE PLASTICIZED WITH BUTYRYL-N-TRIHEXYL CITRATE
    GULLIKSSON, H
    SHANWELL, A
    WIKMAN, A
    REPPUCCI, AJ
    SALLANDER, S
    UDEN, AM
    VOX SANGUINIS, 1991, 61 (03) : 165 - 170
  • [25] Preparation of intercalated hydrotalcite materials and its effect on thermal stability properties of polyvinyl chloride
    Du, Guifang
    Duan, Jinsheng
    Jia, Peijie
    Liu, Zhaogang
    Feng, Fushan
    Hu, Yanhong
    Wu, Jinxiu
    Zhang, Xiaowei
    Li, Jianfei
    PROGRESS IN RUBBER PLASTICS AND RECYCLING TECHNOLOGY, 2024, 40 (04) : 357 - 377
  • [26] Effective organic stabilisers for transparent and colourless materials based on polyvinyl chloride
    Potemkina, O.V.
    Kuvshinova, S.A.
    Gavrilova, A.O.
    Koifman, O.I.
    International Polymer Science and Technology, 2014, 41 (10) : 59 - 60
  • [27] Toxic phthalate-free and highly plasticized polyvinyl chloride materials from non-timber forest resources in plantation
    Jia, Puyou
    Ma, Yufeng
    Song, Fei
    Hu, Yun
    Zhang, Chaoqun
    Zhou, Yonghong
    REACTIVE & FUNCTIONAL POLYMERS, 2019, 144
  • [28] Graft modification of polyvinyl chloride with epoxidized biomass-based monomers for preparing flexible polyvinyl chloride materials without plasticizer migration
    Jia, P.
    Ma, Y.
    Kong, Q.
    Xu, L.
    Hu, Y.
    Hu, L.
    Zhou, Y.
    MATERIALS TODAY CHEMISTRY, 2019, 13 : 49 - 58
  • [29] Enhanced thermal conductivity of plasticized polyvinyl chloride composites based on 2D structural regulation of flaky graphite
    Zhang, Han
    Jia, Yu
    Yang, Jie
    Wang, Zhongpei
    Zhang, Jun
    DIAMOND AND RELATED MATERIALS, 2022, 129
  • [30] RAT PERITONEAL IMPLANTATION TEST - A NEW METHOD FOR TISSUE TOXICITY TESTING OF URINARY CATHETERS
    TALJA, M
    BRITISH JOURNAL OF UROLOGY, 1985, 57 (03): : 329 - 333