Oxoammonium-Catalyzed Oxidation of N-Substituted Amines

被引：3

作者：

Rein, Jonas ^{[1
]}

Gorski, Bartosz ^{[1
]}

Cheng, Yukun ^{[1
]}

Lei, Zhen ^{[2
]}

Buono, Frederic ^{[2
]}

Lin, Song ^{[1
]}

机构：

[1] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

[2] Boehringer Ingelheim Pharmaceut Inc, Chem Dev US, Ridgefield, CT 06877 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 146卷 / 46期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

OPTIMIZATION; TEMPO;

D O I：

10.1021/jacs.4c11758

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the development of oxoammonium-catalyzed oxidation of N-substituted amines via a hydride transfer mechanism. Steric and electronic tuning of catalyst led to complementary sets of conditions that can oxidize a broad scope of carbamates, sulfonamides, ureas, and amides into the corresponding imides. The reaction was further demonstrated on a 100-g scale using a continuous flow setup.

引用

页码：31412 / 31419

页数：8

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