Significance of u-PA and PAI-1 expression on diseased glomeruli

被引：0

作者：

Hong, Yin-Feng ^{[1
]}

Zhang, Zhi-Gang ^{[2
]}

Zhang, Xiu-Rong ^{[2
]}

Guo, Mu-Yi ^{[2
]}

机构：

[1] Dept. of Histology and Embryology, Shanghai Medical College for Staff, Shanghai 200237, China

[2] Department of Pathology, School Basic Medical Science, Fudan University, Shanghai 200032, China

来源：

Fudan University Journal of Medical Sciences | 2001年 / 28卷 / 01期

关键词：

Biopsy - Collagen - Patient treatment;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose: To investigate the significance of u-PA and PAI-1 expression in various types of glomerulonephritis. Methods: The expression level of u-PA, PAI-1, type-IV collagen and PCNA positive nuclei in 120 cases of renal biopsies from patients with various types of glomerulonephritis were detected by immunohistochemical method. Both the staining intensity of u-PA and PAI-1 in glomeruli were quantitatively analyzed by image analysis. Results: The expression intensity of u-PA and PAI-1 was different in varous types of glomerulonephritis, which were significantly higher than that of the minor lesion group. Meanwhile, the intensity of PAI-1 stain was significantly higher than that of u-PA in various types of glomerulonephritis (P<0.05). The increase of u-PA expression was closely related to increase of type-IV collagen synthesis and hypercellularity in glomeruli(r = 0.761 and 0.811, P < 0.05), while the expression of PAI-1 was closely related to the increase of Col-IV synthesis other than the cell proliferation in the glomeruli. Conclusions: The over expression of u-PA and PAI-1 may play an important role in contributing to the pathogenesis and development of glomerulonephritis.

引用

页码：17 / 20

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