Micro-fabricated electrochemical insulin sensor modified with RuOx nano particles

Insulin detection is significant in clinical study, but the lack of effective detection methods impedes its clinical applications. In this work, the carbon microelectrode fabricated with MEMS (micro-electromechanical system) and C-MEMS (complex micro-electromechanical system) technology is applied for insulin detection. The carbon microelectrodes were fabricated through the pyrolysis of photoresist and showed good electrochemical performance. After electro-deposition of ruthinium oxide nano particles on the electrode surface, the insulin oxidation is electro-catalyzed and its electrochemical detection is realized at 0.7 V. The sensor has a sensitivity of 1 nA/μM for insulin detection, with a detection limit of 800 nM. Electrochemical measurement shows that the sensor has advantages of high sensitivity, fast response and usability for real time on-site detection. ©, 2015, Univ. of Electronic Science and Technology of China. All right reserved.