Transforming growth factor-?1 remodels the cytoskeleton organization of mature dendritic cells via Smad2/3 signaling pathway

Dendritic cells (DCs) are the most potent professional antigen presenting cells as now known, which play critical roles in the initiation, programming and regulation of the immune response. Transforming growth factor-?1 (TGF-?1), one of the major suppressive cytokines in tumor microenvironment, can deteriorate the biomechanical characteristics and motility of mature dendritic cells (mDCs)?but the underlying molecular mechanisms are not well defined. In this study, the effects of TGF-?1 on the motilities and T cell priming capabilities of mDCs as well as the molecular regulatory mechanisms were investigated. The results showed that the cytoskeleton (F-actin) organizations of mDCs were abnormally remodeled by TGF-?1. Simultaneously, the migration and immune priming capabilities of mDCs were impaired by TGF-?1 via Smad2/3 signaling pathway. It's significant for further understanding the interaction of DCs and TGF-?1 in tumor host, as well as the immune escape mechanism of cancer, which may be important for enhancing the clinical efficiency of DCs-based immunotherapy against cancer. Copyright © 2018 Tech Science Press