Mitochondria as multifaceted regulators of ferroptosis

被引:1
|
作者
Jingyi Guo [1 ,2 ]
Yunhao Zhou [1 ,2 ,3 ]
Dingfei Liu [1 ,2 ,3 ]
Mengfei Wang [1 ,2 ,3 ]
Yi Wu [1 ,2 ]
Daolin Tang [4 ]
Xingguo Liu [1 ,2 ,5 ]
机构
[1] CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
[2] Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, China-New Zealand Joint Laboratory on Biomedicine and Health, CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine, Institute for Stem Cell and Regeneration,
[3] University of Chinese Academy of Sciences
[4] Department of Surgery, UT Southwestern Medical Center
[5] Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of
关键词
D O I
暂无
中图分类号
Q244 [细胞内膜系统];
学科分类号
摘要
Mitochondria are well known to be "energy factories" of the cell as they provide intracellular ATP via oxidative phosphorylation. Interestingly,they also function as a "cellular suicidal weapon store" by acting as a key mediator of various forms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis. Ferroptosis, distinct from the other types of regulated cell death, is characterized by iron-dependent lipid peroxidation and subsequent plasma membrane rupture. Growing evidence suggests that an impaired ferroptotic response is implicated in various diseases and pathological conditions, and this impaired response is associated with dramatic changes in mitochondrial morphology and function. Mitochondria are the center of iron metabolism and energy production, leading to altered lipid peroxidation sensitivity. Although a growing number of studies have explored the inextricable link between mitochondria and ferroptosis,the role of this organelle in regulating ferroptosis remains unclear. Here, we review recent advances in our understanding of the role of mitochondria in ferroptosis and summarize the characteristics of this novel iron-based cellular suicide weapon and its arsenal. We also discuss the importance of ferroptosis in pathophysiology, including the need for further understanding of the relationship between mitochondria and ferroptosis to identify combinatorial targets that are essential for the development of successful drug discovery.
引用
收藏
页码:134 / 148
页数:15
相关论文
共 50 条
  • [21] Calcium signals as regulators of ferroptosis in cancer
    Stejerean-Todoran, Ioana
    Gibhardt, Christine S.
    Bogeski, Ivan
    CELL CALCIUM, 2024, 124
  • [22] The multifaceted effects of mitochondria in kidney diseases
    Xue, Jia-Le
    Ji, Jia-Ling
    Zhou, Yan
    Zhang, Yao
    Liu, Bi-Cheng
    Ma, Rui-Xia
    Li, Zuo-Lin
    MITOCHONDRION, 2024, 79
  • [23] The multifaceted contributions of mitochondria to cellular metabolism
    Jessica B. Spinelli
    Marcia C. Haigis
    Nature Cell Biology, 2018, 20 : 745 - 754
  • [24] Multifaceted deaths orchestrated by mitochondria in neurones
    Nagley, Phillip
    Higgins, Gavin C.
    Atkin, Julie D.
    Beart, Philip M.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2010, 1802 (01): : 167 - 185
  • [25] The multifaceted contributions of mitochondria to cellular metabolism
    Spinelli, Jessica B.
    Haigis, Marcia C.
    NATURE CELL BIOLOGY, 2018, 20 (07) : 745 - 754
  • [26] Transcriptional repressors: multifaceted regulators of gene expression
    Reynolds, Nicola
    O'Shaughnessy, Aoife
    Hendrich, Brian
    DEVELOPMENT, 2013, 140 (03): : 505 - 512
  • [27] tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators
    Li, Yun
    Yu, Zongyu
    Jiang, Wenlin
    Lyu, Xinyi
    Guo, Ailian
    Sun, Xiaorui
    Yang, Yiting
    Zhang, Yunfang
    BIOMOLECULES, 2024, 14 (10)
  • [28] GAP junctions: multifaceted regulators of neuronal differentiation
    Talukdar, Sarmistha
    Emdad, Luni
    Das, Swadesh K.
    Fisher, Paul B.
    TISSUE BARRIERS, 2022, 10 (01):
  • [29] Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity
    Deshwal, Soni
    Fiedler, Kai Uwe
    Langer, Thomas
    ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89, 2020, 89 : 501 - 528
  • [30] Mitochondria: Central regulators of apoptosis
    Newmeyer, DD
    MOLECULAR BIOLOGY OF THE CELL, 1997, 8 : 2032 - 2032