Evaluation of quinoxaline derivatives as potential ergosterol biosynthesis inhibitors: design, synthesis, ADMET, molecular docking studies, and antifungal activities

被引:0
|
作者
Fayed, Eman A. [1 ]
Ebrahim, Maha A. [1 ]
Fathy, Usama [2 ]
Saeed, Hoda S. El [1 ]
Khalaf, Wafaa S. [3 ]
机构
[1] Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt
[2] Applied Organic Chemistry Department, National Research Centre, 33 El Bohouth st. (former El Tahrir st.), Dokki-Giza,P.O.12622, Egypt
[3] Department of Microbiology and Immunology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Nasr City,11754, Egypt
关键词
D O I
暂无
中图分类号
学科分类号
摘要
62
引用
收藏
相关论文
共 50 条
  • [21] Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors
    Celik, Ismail
    Ayhan-Kilcigil, Gulgun
    Guven, Berna
    Kara, Zumra
    Gurkan-Alp, A. Selen
    Karayel, Arzu
    Onay-Besikci, Arzu
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 173 : 240 - 249
  • [22] Efficient synthesis, crystallography study, antibacterial/antifungal activities, DFT/ADMET studies and molecular docking of novel α-aminophosphonates
    Bahadi, Rania
    Berredjem, Malika
    Benzaid, Chahrazed
    Bouchareb, Fouzia
    Dekir, Ali
    Djendi, Manel Lina
    Ibrahim-Ouali, Malika
    Boussaker, Meriem
    Bouacida, Sofiane
    Bhat, Ajmal Rashid
    Ahmed, Sumeer
    Bachari, Khaldoun
    Redjemia, Rayenne
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1289
  • [23] New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies
    Alanazi, Mohammed M.
    Elkady, Hazem
    Alsaif, Nawaf A.
    Obaidullah, Ahmad J.
    Alkahtani, Hamad M.
    Alanazi, Manal M.
    Alharbi, Madhawi A.
    Eissa, Ibrahim H.
    Dahab, Mohammed A.
    RSC ADVANCES, 2021, 11 (48) : 30315 - 30328
  • [24] Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
    Hawash, Mohammed
    Jaradat, Nidal
    Abualhasan, Murad
    Sukuroglu, Murat Kadir
    Qaoud, Mohammed T. T.
    Kahraman, Deniz Cansen
    Daraghmeh, Heba
    Maslamani, Leen
    Sawafta, Mais
    Ratrout, Ala
    Issa, Linda
    BMC CHEMISTRY, 2023, 17 (01)
  • [25] Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
    Mohammed Hawash
    Nidal Jaradat
    Murad Abualhasan
    Murat Kadır Şüküroğlu
    Mohammed T. Qaoud
    Deniz Cansen Kahraman
    Heba Daraghmeh
    Leen Maslamani
    Mais Sawafta
    Ala Ratrout
    Linda Issa
    BMC Chemistry, 17
  • [26] Synthesis, docking studies, and in silico ADMET predictions of some new derivatives of pyrimidine as potential KSP inhibitors
    Umer Rashid
    Syed Fahad Hassan
    Samina Nazir
    Abdul Wadood
    Muhammad Waseem
    Farzana Latif Ansari
    Medicinal Chemistry Research, 2015, 24 : 304 - 315
  • [27] Synthesis, docking studies, and in silico ADMET predictions of some new derivatives of pyrimidine as potential KSP inhibitors
    Rashid, Umer
    Hassan, Syed Fahad
    Nazir, Samina
    Wadood, Abdul
    Waseem, Muhammad
    Ansari, Farzana Latif
    MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (01) : 304 - 315
  • [28] Synthesis, Characterization, Antiglycation Evaluation, Molecular Docking, and ADMET Studies of 4-Thiazolidinone Derivatives
    Haque, Ashanul
    Khan, Mohd Wajid Ali
    Alenezi, Khalaf M.
    Soury, Raoudha
    Khan, Muhammad S.
    Ahamad, Shahzaib
    Mushtaque, Md.
    Gupta, Dinesh
    ACS OMEGA, 2023, 9 (01): : 1810 - 1820
  • [29] Synthesis, In Vitro Antimicrobial Evaluation, ADMET Properties, and Molecular Docking Studies of Novel Thiazole Derivatives
    J. N. Jatiya
    A. S. Patel
    M. M. Savant
    Russian Journal of General Chemistry, 2023, 93 : 2621 - 2631
  • [30] Synthesis, In Vitro Antimicrobial Evaluation, ADMET Properties, and Molecular Docking Studies of Novel Thiazole Derivatives
    Jatiya, J. N.
    Patel, A. S.
    Savant, M. M.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2023, 93 (10) : 2621 - 2631