Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons

被引：1

作者：

Aamri M.E. ^{[1
]}

Yammouri G. ^{[1
]}

Mohammadi H. ^{[1
]}

Amine A. ^{[1
]}

Korri-Youssoufi H. ^{[2
]}

机构：

[1] Laboratory of Process Engineering & Environment, Faculty of Sciences and Techniques, Hassan II, University of Casablanca, B.P.146, Mohammedia

[2] Université Paris-Saclay, CNRS, Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), Equipe de Chimie Biorganique et Bioinorganique (ECBB), Bât 420, 2 Rue du Doyen Georges Poitou, Orsay

来源：

Biosensors | 2020年 / 10卷 / 11期

关键词：

cancer biomarker; catalysts; electrochemical biosensor; microRNA; RedOx indicator;

D O I：

10.3390/BIOS10110186

中图分类号：

学科分类号：

摘要：

Cancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection. MicroRNA (miRNA) is an RNA cancer biomarker where the expression level in body fluid is strongly correlated to cancer. Various biosensors involving the detection of miRNA for cancer diagnosis were developed. The present review offers a comprehensive overview of the recent developments in electrochemical biosensor for miRNA cancer marker detection from 2015 to 2020. The review focuses on the approaches to direct miRNA detection based on the electrochemical signal. It includes a RedOx-labeled probe with different designs, RedOx DNA-intercalating agents, various kinds of RedOx catalysts used to produce a signal response, and finally a free RedOx indicator. Furthermore, the advantages and drawbacks of these approaches are highlighted. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

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