Isolation, Characterization and Application of Exosome-Like Nanoparticles from Fruits and Vegetables: A Review

被引：1
|
作者：
Yang M. [1 ]
Liu S. [1 ]
Zhang J. [1 ]
Ran L. [1 ]
Chen Z. [2 ]
Ma C. [1 ]
机构：
[1] College of Biological Sciences and Technology, Beijing Forestry University, Beijing
[2] School of Technology, Beijing Forestry University, Beijing
来源：
Shipin Kexue/Food Science | 2021年 / 42卷 / 09期
关键词：
Carrier; Exosomes; Extracellular vesicles; Fruits and vegetables;
D O I：
10.7506/spkx1002-6630-20200418-240
中图分类号：
学科分类号：
摘要：
The exosome-like nanoparticles (ELNs) in fruits and vegetables are nano-scale extracellular vesicles released by fruit and vegetable cells, with similar structures to the exosomes of mammal cells, and have significantly varying lipid, protein and nucleic acid profiles as well as unique biological functions. In this review, the progress that has been made in studies on the ELNs in dozens of fruits and vegetables since 2013 are summarized with a special focus on the methods used for ELNs extraction and characterization and on the differences in the chemical profiles including lipids, proteins, and nucleic acids of ELNs from different plant sources. Also, the potential health benefits and application as drug carriers of these ELNs are reviewed. This article is expected to provide enlightenments for further investigations on ELNs from fruits and vegetables. © 2021, China Food Publishing Company. All right reserved.
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页码：355 / 361
页数：6
相关论文
共 47 条
  • [31] PEREZ-BERMUDEZ P, BLESA J, SORIANO J M, Et al., Extracellular vesicles in food: experimental evidence of their secretion in grape fruits, European Journal of Pharmaceutical Sciences, 98, pp. 40-50, (2017)
  • [32] REGENTE M, PINEDO M, SAN C H, Et al., Plant extracellular vesicles are incorporated by a fungal pathogen and inhibit its growth[J], Journal of Experimental Botany, 68, 20, pp. 5485-5495, (2017)
  • [33] WANG B M, ZHUANG X Y, DENG Z B, Et al., Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit, Molecular Therapy, 22, 3, pp. 522-534, (2014)
  • [34] ZHANG M Z, VIENNOIS E, PRASAD M, Et al., Edible gingerderived nanoparticles: a novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer, Biomaterials, 101, pp. 321-340, (2016)
  • [35] YANG X X, SUN C, WANG L, Et al., New insight into isolation, identification techniques and medical applications of exosomes, Journal of Controlled Release, 308, pp. 119-129, (2019)
  • [36] RECORD M., Exosome-like nanoparticles from food: protective nanoshuttles for bioactive cargo, Molecular Therapy, 21, 7, pp. 1294-1296, (2013)
  • [37] TENG Yun, REN Yi, SAYED M, Et al., Plant-derived exosomal micrornas shape the gut microbiota[J], Cell Host Microbe, 24, 5, pp. 637-652, (2018)
  • [38] CONSOLE L, SCALISE M, INDIVERI C., Exosomes in inflammation and role as biomarkers, Clinica Chimica Acta International Journal of Clinical Chemistry, 488, pp. 165-171, (2019)
  • [39] TKACH M, THERY C., Communication by extracellular vesicles: Where we are and where we need to go, Cell, 164, 6, pp. 1226-1232, (2016)
  • [40] EFTYCHI C, SCHWARZER R, VLANTIS K, Et al., Temporally distinct functions of the cytokines IL-12 and IL-23 drive chronic colon inflammation in response to intestinal barrier impairment, Immunity, 51, 2, pp. 367-380, (2019)
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