Nanoparticle-laden contact lens for controlled release of vancomycin with enhanced antibiotic efficacy

被引:8
|
作者
Tong W.Y. [1 ,2 ]
Tan W.-N. [3 ]
Kamarul Azizi M.A. [2 ]
Leong C.R. [2 ]
El Azab I.H. [4 ]
Lim J.W. [5 ,6 ]
Mahmoud M.H.H. [7 ]
Dailin D.J. [8 ,9 ]
Ibrahim M.M. [7 ]
Chuah L.F. [10 ]
机构
[1] Universiti Kuala Lumpur, Branch Campus Institute of Medical Science Technology, A1, 1, Jalan TKS 1, Taman Kajang Sentral, Selangor, Kajang
[2] Universiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Bioengineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, Alor Gajah, Melaka
[3] School of Distance Education, Universiti Sains Malaysia, Penang, Minden
[4] Department of Food Science and Nutrition, College of Science, Taif University, P.O. box 11099, Taif
[5] HICoE-Centre for Biofuel and Biochemical Research, Institute of Self Sustainable Building, Department of Fundamental and Applied Sciences, Universiti Teknologi PETRONAS, Perak Darul Ridzuan, Seri Iskandar
[6] Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai
[7] Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif
[8] Institute of Bioproduct Development, Universiti Teknologi Malaysia, Johor
[9] Department of Bioprocess and Polymer Engineering, Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, Johor
[10] Faculty of Maritime Studies, Universiti Malaysia Terengganu, Terengganu
关键词
Controlled release; Drug delivery system; Nanoparticles; Polyvinyl alcohol; Vancomycin;
D O I
10.1016/j.chemosphere.2023.139492
中图分类号
学科分类号
摘要
Vancomycin is the last resort antibiotic for the treatment of severe bacterial keratitis. Its clinical application is limited due to its hydrophilicity and high molecular weight. To overcome this, this study aims to develop nanoparticles-laden contact lens for controlled ocular delivery of vancomycin. Polyvinyl alcohol (PVA) was used as encapsulant material. The nanoparticles had a negative surface charge and an average size of 147.6 nm. A satisfactory encapsulation efficiency (61.24%) was obtained. The release profile was observed to be slow and sustained, with a release rate of 1.29 μL mg−1 h−1 for 48 h. Five out of 6 test bacteria were suppressed by vancomycin nanoparticles-laden contact lens. Vancomycin is generally ineffective against Gram-negative bacteria and unable to pass through the outer membrane barrier. In this study, vancomycin inhibited Proteus mirabilis and Pseudomonas aeruginosa. Nano-encapsulation enables vancomycin to penetrate the Gram-negative cell wall and further destroy the bacterial cells. On Hohenstein challenge test, all test bacteria exhibited significant reduction in growth when exposed to vancomycin nanoparticles-laden contact lens. This study created an effective and long-lasting vancomycin delivery system via silicone hydrogel contact lenses, by using PVA as encapsulant. The antibiotic efficacy and vancomycin release should be further studied using ocular in vivo models. © 2023 Elsevier Ltd
引用
收藏
相关论文
共 50 条
  • [41] Antimicrobial efficacy of a new antibiotic-loaded poly(hydroxybutyric-co-hydroxyvaleric acid) controlled release system
    Rossi, S
    Azghani, AO
    Omri, A
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 54 (06) : 1013 - 1018
  • [42] Microcystis aeruginosa-laden water treatment using enhanced coagulation by calcium peroxide/Fe(II): Simultaneously enhanced algae removal, controlled AOM release and improved water quality
    Xin, Huaijia
    Tang, Yulin
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [43] Adjusting biomaterial composition to achieve controlled multiple-day release of dexamethasone from an extended-wear silicone hydrogel contact lens
    Kaczmarek, James C.
    Tieppo, Arianna
    White, Charles J.
    Byrne, Mark E.
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2014, 25 (01) : 88 - 100
  • [44] Photosensitive Pt(IV)-azide prodrug-loaded nanoparticles exhibit controlled drug release and enhanced efficacy in vivo
    Xiao, Haihua
    Noble, Gavin T.
    Stefanick, Jared F.
    Qi, Ruogu
    Kiziltepe, Tanyel
    Jing, Xiabin
    Bilgicer, Basar
    JOURNAL OF CONTROLLED RELEASE, 2014, 173 : 11 - 17
  • [45] Demineralized bone matrix paste formulated with biomimetic PLGA microcarriers for the vancomycin hydrochloride controlled delivery: Release profile, citotoxicity and efficacy against S. aureus
    Govoni, Marco
    Lamparelli, Erwin P.
    Ciardulli, Maria C.
    Santoro, Antonietta
    Oliviero, Antonio
    Palazzo, Ida
    Reverchon, Ernesto
    Vivarelli, Leonardo
    Maso, Alessandra
    Storni, Elisa
    Donati, Maria E.
    Ruspaggiari, Gianluca
    Maffulli, Nicola
    Fini, Milena
    Della Porta, Giovanna
    Dallari, Dante
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 582
  • [46] Smart controlled-release avermectin nanopesticides based on metal-organic frameworks with large pores for enhanced insecticidal efficacy
    Liu, Jincan
    Xu, Dejin
    Xu, Guangchun
    Li, Xiaona
    Dong, Jiangtao
    Luan, Xingkun
    Du, Xuezhong
    CHEMICAL ENGINEERING JOURNAL, 2023, 475
  • [47] Development of stimuli-responsive chitosan based hydrogels with anticancer efficacy, enhanced antibacterial characteristics, and applications for controlled release of benzocaine
    Raza, Muhammad Asim
    Gull, Nafisa
    Lee, Se -Won
    Seralathan, Kamala-Kannan
    Park, Sang Hyun
    JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2022, 109 : 210 - 220
  • [48] A DOUBLE-MASKED PLACEBO-CONTROLLED, EVALUATION OF THE EFFICACY AND SAFETY OF LOTEPREDNOL ETABONATE IN THE TREATMENT OF CONTACT-LENS ASSOCIATED GIANT PAPILLARY CONJUNCTIVITIS
    HOWES, JF
    ASBELL, PA
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1995, 36 (04) : S630 - S630
  • [49] Enzyme-responsive peptide dendrimer-gemcitabine conjugate as a controlled-release drug delivery vehicle with enhanced antitumor efficacy
    Zhang, Chengyuan
    Pan, Dayi
    Li, Jin
    Hu, Jiani
    Bains, Ashika
    Guys, Nicholas
    Zhu, Hongyan
    Li, Xiaohui
    Luo, Kui
    Gong, Qiyong
    Gu, Zhongwei
    ACTA BIOMATERIALIA, 2017, 55 : 153 - 162
  • [50] Controlled synthesis and enhanced catalytic activity of well-defined close-contact Pd-ZnO nanostructures using PdZn ordered nanoparticle precursors
    Yin, Hongfeng
    Li, Qi
    Zhou, Shenghu
    Yu, Hongbo
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258