Synthesis and evaluation of novel biaryl oxazolidinones effective against gram-positive bacterial infections

被引：0

作者：

Bhawsar, Satish ^{[1
]}

Shaikh, Mohammad ^{[1
]}

Joshi, Sanjeev ^{[1
]}

Mishra, Amit ^{[1
]}

Pavase, Laxmikant ^{[1
]}

Chavan, Vijay ^{[1
]}

Kale, Amol ^{[1
]}

Kayastha, Abhijeet K. ^{[1
]}

Yeole, Ravindra ^{[1
]}

Bhagwat, Sachin ^{[1
]}

Patel, Mahesh ^{[1
]}

机构：

[1] MIDC, Wockhardt Res Ctr, D-4, Aurangabad 431006, Maharashtra, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2024年 / 33卷 / 10期

关键词：

Biaryl oxazolidinones; antibiotics; gram-positive; MRSA; WCK; 3999; 4603;

D O I：

10.1007/s00044-024-03287-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oxazolidinones are synthetic antibiotic class of compounds characterized by chemical structure, cyclic carbamate with 'S' configuration of substituent at C-5 position. The synthesis of oxazolidinones has gained increasing interest due to their unique mechanism of action that assures high antibiotic efficiency and low susceptibility to resistance mechanisms. Biaryl oxazolidinones are second-generation oxazolidinone (e.g. Tedizolid) having potency against multidrug-resistant (MDR) gram-positive pathogens including MRSA, VRE, penicillin-resistant S. pneumoniae and linezolid-resistant strains. The current manuscript covers structure activity based synthesis of 21 oxazolidinone analogs prepared through various chemical modifications. These novel biaryl oxazolidinones are prepared with the objective to increase spectrum of activity against multidrug-resistant Gram-positive bacteria. [GRAPHICS] .

引用

页码：1887 / 1896

页数：10

共 50 条

[41] Dalbavancin and telavancin:: novel lipoglycopeptides for the treatment of Gram-positive infections
Zhanel, George G.
Trapp, Shannon
Gin, Alfred S.
DeCorby, Mel
Lagace-Wiens, Philippe R. S.
Rubinstein, Ethan
Hoban, Daryl J.
Karlowsky, James A.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2008, 6 (01) : 67 - 81
[42] Iclaprim, a Novel Diaminopyrimidine for the Treatment of Resistant Gram-Positive Infections
Sincak, Carrie A.
Schmidt, Justin M.
ANNALS OF PHARMACOTHERAPY, 2009, 43 (06) : 1107 - 1114
[43] Novel antibacterial agents for the treatment of serious Gram-positive infections
Abbanat, D
Macielag, M
Bush, K
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2003, 12 (03) : 379 - 399
[44] Novel Ensemble Predictor for Gram-positive Bacterial Protein Sequences
Zahur, Awais
Majid, Abdul
Kausar, Nabeela
PROCEEDINGS OF 2014 12TH INTERNATIONAL CONFERENCE ON FRONTIERS OF INFORMATION TECHNOLOGY, 2014, : 319 - 324
[45] A novel bioassay to identify anti-virulence leads against gram-positive bacterial pathogens
Todd, D. A.
Zich, D. B.
Horswill, A. R.
Cech, N. B.
PLANTA MEDICA, 2015, 81 (11) : 875 - 875
[46] GRAM-POSITIVE INFECTIONS RELATED TO CAPD
WILLIAMS, JD
COLES, GA
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 27 : 31 - 35
[47] Antibiotics for Gram-Positive Bacterial Infection: Vancomycin, Teicoplanin, Quinupristin/Dalfopristin, Oxazolidinones, Daptomycin, Telavancin, and Ceftaroline
Nailor, Michael D.
Sobel, Jack D.
MEDICAL CLINICS OF NORTH AMERICA, 2011, 95 (04) : 723 - +
[48] Gram-positive infections and quinolones in neutropenia
Altclas, J
Costantini, P
Dictar, M
ANNALS OF INTERNAL MEDICINE, 1997, 126 (10) : 830 - 830
[49] Use of linezolid against multidrug-resistant gram-positive infections
Allan R. Tunkel
Current Infectious Disease Reports, 2000, 2 (5) : 387 - 388
[50] DEVELOPMENTS IN TREATMENT OF GRAM-POSITIVE INFECTIONS
WHITBY, M
CURRENT OPINION IN INFECTIOUS DISEASES, 1989, 2 (03) : 349 - 352

← 1 2 3 4 5 →