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Metabolomics for hematologic malignancies: Advances and perspective
被引:0
|作者:
Li, Xinglan
[1
]
Xu, Mengyu
[1
]
Chen, Yanying
[2
]
Zhai, Yongqing
[3
]
Li, Junhong
[1
]
Zhang, Ning
[4
]
Yin, Jiawei
[5
,6
,7
]
Wang, Lijuan
[5
,6
,7
,8
]
机构:
[1] Shandong Second Med Univ, Linyi Peoples Hosp, Linyi, Peoples R China
[2] Linyi Peoples Hosp, Hematol Lab, Linyi, Peoples R China
[3] Linyi Peoples Hosp, Dept Orthoped, Linyi, Peoples R China
[4] Linyi Peoples Hosp, Dept Anesthesiol, Linyi, Peoples R China
[5] Linyi Peoples Hosp, Cent Lab, Linyi, Peoples R China
[6] Key Lab Tumor Biol, Linyi, Peoples R China
[7] Xuzhou Med Univ, Key Lab Translat Oncol, Xuzhou, Peoples R China
[8] Linyi Peoples Hosp, Dept Hematol, Linyi, Peoples R China
来源:
关键词:
amino acid metabolism;
glucose metabolism;
leukemia;
lipid metabolism;
lymphoma;
myeloma;
ACUTE MYELOID-LEUKEMIA;
B-CELL LYMPHOMA;
METABOLISM;
SERUM;
MICROENVIRONMENT;
CHROMATOGRAPHY;
PROLIFERATION;
BIOMARKERS;
SIGNATURE;
RESISTANT;
D O I:
10.1097/MD.0000000000039782
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
With the use of advanced technology, metabolomics allows for a thorough examination of metabolites and other small molecules found in biological specimens, blood, and tissues. In recent years, metabolomics has been recognized that is closely related to the development of malignancies in the hematological system. Alterations in metabolomic pathways and networks are important in the pathogenesis of hematologic malignancies and can also provide a theoretical basis for early diagnosis, efficacy evaluation, accurate staging, and individualized targeted therapy. In this review, we summarize the progress of metabolomics, including glucose metabolism, amino acid metabolism, and lipid metabolism in lymphoma, myeloma, and leukemia through specific mechanisms and pathways. The research of metabolomics gives a new insight and provides therapeutic targets for the treatment of patients with hematologic malignancies.
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页数:15
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