Evaluating the relationship of affinity, functional avidity, and in vivo potency in KIR-CAR T cells

被引：0
|
作者：
Xu, Jun
Nunez-Cruz, Selene
Leferovich, John M.
Gulendran, Gayathri
Zhang, Chune
Yucel, Nora D.
Blair, Megan C.
Stanley, William S.
Johnson, Laura A.
Siegel, Don L.
Milone, Michael C.
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-6332
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
6332
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Functional avidity directs T-cell fate in autoreactive CD4+ T cells
    Mallone, R
    Kochik, SA
    Reijonen, H
    Carson, B
    Ziegler, SF
    Kwok, WW
    Nepom, GT
    BLOOD, 2005, 106 (08) : 2798 - 2805
  • [42] In Vitro and In Vivo Activity of a Lipid Nanoparticle System for the In Vivo Generation of CAR T Cells
    Lemgart, Viktor
    Richards, Jennifer
    Strauss, Laura
    Jiao, Jing
    Quido, Brandon
    Powers, Laura
    Caron, Allison
    Shin, Eyoung
    Boesch, Austin
    Shah, Dharini
    Le, Tiffany
    Kunden, Rasika
    Stewart, Samantha
    Nasimi, Fazila
    Maiti, Sampa
    Ali, Mir
    Lihoradova, Olga
    Griset, Aaron
    Borges, Christopher M.
    Kuhlman, William
    Lawendowski, Carla
    Nielsen, Ulrik
    Fantin, Valeria
    Drummond, Daryl
    Shaffer, Donald
    Sawyer, Andrew J.
    BLOOD, 2024, 144 : 3421 - 3422
  • [43] RELATIVE AFFINITY AND AVIDITY OF ANTIGEN-BINDING RECEPTORS OF T AND B ROSETTE-FORMING CELLS
    WILSON, JD
    FELDMANN, M
    NATURE-NEW BIOLOGY, 1973, 245 (145): : 177 - 180
  • [44] Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells
    Alka, Dwivedi
    Atharva, Karulkar
    Sarbari, Ghosh
    Afrin, Rafiq
    Rahul, Purwar
    FRONTIERS IN IMMUNOLOGY, 2019, 9
  • [45] Relationship of 2D Affinity to T Cell Functional Outcomes
    Kolawole, Elizabeth M.
    Lamb, Tracey J.
    Evavold, Brian D.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (21) : 1 - 20
  • [46] Surface Density of CAR Molecules May Modulate the Kinetics of CAR-T Cells In Vivo
    Li, Jianqiang
    Ho, Jin-Yuan
    Wang, Lin
    Niu, Xing
    Ba, Min
    Wang, Qinglong
    Yang, Junfang
    Zhang, Xian
    Chen, Dandan
    Lu, Peihua
    BLOOD, 2019, 134
  • [47] Dendritic cells require T cells for functional maturation in vivo
    Shreedhar, V
    Moodycliffe, AM
    Ullrich, SE
    Bucana, C
    Kripke, ML
    Flores-Romo, L
    IMMUNITY, 1999, 11 (05) : 625 - 636
  • [48] Kinetics and potency of T cell and CAR-T cell mediated cytolysis of glioma stem cells.
    Hayes, Heather Brant
    Logun, Meghan T.
    Chvatal, Stacie A.
    Mueller, Katie
    Piscopo, Nicole
    Das, Amritava
    Saha, Krishanu
    Millard, Daniel C.
    Karumbaiah, Lohitash
    CANCER RESEARCH, 2021, 81 (13)
  • [49] Biomaterials promote in vivo generation and immunotherapy of CAR-T cells
    Qin, Ya-Ting
    Li, Ya-Ping
    He, Xi-Wen
    Wang, Xi
    Li, Wen-You
    Zhang, Yu-Kui
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [50] Stabilization of long CAR T cells is crucial for in vivo antitumor efficacy
    Paavilainen, Henrik
    Koski, Jan
    Nikoskelainen, Veera
    Elmadani, Manar
    Elbasani, Endrit
    Hekim, Can
    Ihantola, Emmi-Leena
    Kergourlay, Virginie
    Vehmaan-Kreula, Pirjo
    Nyman, Marie
    Kalke, Kiira
    Nurmi, Markus
    Monzo, Hector
    Ojala, Paivi
    Autio, Anu
    Korhonen, Matti
    Thotakura, Anil
    CANCER RESEARCH, 2024, 84 (06)
12345