Direct oral Penicillin Allergy Test is as safe as Skin Tests

Oral provocation serves as the gold standard for proving that there is no penicillin allergy - however, there are few studies that support a direct oral penicillin test without prior prick and intracutaneous testing in adults. Copaescu et al. investigated whether a direct oral penicillin test is non-inferior to the standard treatment with a skin test followed by oral provocation in low-risk allergy patients.