Neurotoxicity of Amyloid Beta and its Association with other Biomarkers in Pathogenesis of Alzheimer's Disease: A Narrative Review

被引：0

作者：

Sah, Ram Prakash ^{[1
]}

Vidya, C. S. ^{[1
]}

Pereira, Pratibha ^{[2
]}

Jayaram, Shubha ^{[3
]}

Yadav, Anshu Kumar ^{[3
]}

Sujatha, P. ^{[3
]}

机构：

[1] JSS Med Coll, Dept Anat, Mysore, Karnataka, India

[2] JSS Med Coll, Dept Geriatr, Mysore, Karnataka, India

[3] Mysore Med Coll, Dept Biochem, Mysore, Karnataka, India

来源：

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH | 2024年 / 18卷 / 10期

关键词：

Biomarkers; Dementia; Memory; Neurodegeneration; MILD COGNITIVE IMPAIRMENT; OXIDATIVE STRESS; MOUSE MODEL; DEMENTIA; ACTIVATION; GENE;

D O I：

10.7860/JCDR/2024/70332.20174

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amyloid beta (A(3) deposition in the brain is regarded as an early toxic effect in the aetiopathogenesis of Alzheimer's Disease (AD). Currently, A(3 is considered a key marker for AD and a promising target for drug development for the future management of debilitating diseases such as AD. However, the pathomechanism of A(3 has not yet been precisely understood in terms of AD patients, specifically regarding the pathological forms of A(3 and how it associates with other biochemical markers to cause dementia. Identifying A(3 as a key hallmark, especially at the earliest stages of the disease, is essential for understanding the progression of AD and its applicability for the development of novel therapeutics aimed at managing cognitive impairment and AD. This review aims to explain the neurotoxicity of A(3 and its correlation with various other biological markers that contribute to the induction of AD and memory deterioration.

引用

页码：AE1 / AE5

页数：5

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