Healthcare is a relatively mature industry field that still has wicked problems. Design science research can help identify non-optimal processes and work practices and suggest redesign and digitalization efforts. Elegant technical solutions to these problems require that design science researchers collaborate with transdisciplinary teams. This track for DESRIST 2022 encourages scholars to submit multidisciplinary submissions with novel solutions to health and social well-being problems on the individual, group, organization, population, country, and world level. The papers in the track include the application of artificial intelligence, the creation of mobile apps for issues such as depression and blood do- nation, and submissions on contemporary topics such as COVID-19 and refugee problems. We identify three subjects that require more research from the DSR community: cost-effective solutions, knowledge management, and longterm evaluations.