Role and functional mechanisms of IL-17/IL-17R signaling in pancreatic cancer (Review)

Interleukin-17 (IL-17), an inflammatory cytokine primarily secreted by T helper 17 cells, serves a crucial role in numerous inflammatory diseases and malignancies via its receptor, IL-17R. In addition to stimulating inflammatory responses, IL-17 exhibits dual functions in tumors, exerting both pro- and antitumor effects. Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy and accounts for >90% of pancreatic cancer cases. PDAC is characterized by a prominent stromal microenvironment with significant heterogeneity, which contributes to treatment resistance. IL-17/IL-17R signaling has a notable effect on tumorigenesis, the tumor microenvironment and treatment efficacy in various cancer types, including PDAC. However, the specific mechanisms of IL-17/IL-17R signaling in pancreatic cancer remain uncertain. This review presents a brief overview of the current knowledge and recent advances in the role and functional mechanisms of IL-17/IL-17R signaling in pancreatic cancer. Furthermore, the potential of IL-17-targeted therapeutic strategies for PDAC treatment is also discussed.