Synthesis and Characterization of Carboxymethylcellulose-Functionalized Magnetite Nanoparticles as Contrast Agents for THz Spectroscopy with Applications in Oncology

被引：1
|
作者：
Schreiner, Oliver Daniel [1 ]
Samoila, Petrisor [2 ]
Schreiner, Thomas Gabriel [1 ,3 ]
Socotar, Diana [1 ]
Ciobanu, Romeo Cristian [1 ]
机构：
[1] Gheorghe Asachi Tech Univ, Dept Elect Measurements & Mat, Iasi 700050, Romania
[2] Petru Poni Inst Macromol Chem, Aleea Grigore Ghica Voda 41A, Iasi 700487, Romania
[3] Univ Med & Pharm Grigore T Popa, Fac Med, Dept Med Specialties 3, Iasi 700115, Romania
来源：
CRYSTALS | 2024年 / 14卷 / 08期
关键词：
magnetite functionalized with carboxymethylcellulose; coprecipitation process; in vitro and in vivo tests of bio-compatibility; dielectric features; contrast agents; broadband THz spectroscopy; TERAHERTZ SPECTROSCOPY; OXIDE NANOPARTICLES; CANCER-DIAGNOSIS; IN-VITRO; TOXICITY;
D O I：
10.3390/cryst14080696
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
This paper describes a process to obtain magnetite functionalized with carboxymethylcellulose via coprecipitation by means of a preliminary stabilization of magnetite in citric acid. The magnetite assemblies successfully passed in vitro and in vivo tests of bio-compatibility. The measured values for the dielectric loss factor are remarkably high, a prerequisite for the assemblies' potential use as contrast agents. Broadband THz spectroscopy analysis was performed to identify the most relevant frequency bands (here, 3.2-4 THz) where the signal difference between normal cells and cancer cells is relevant for the particles' potential use as contrast agents for THz imaging, with applications in oncology.
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页数：16
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