Association between serum α-Klotho levels and osteoarthritis prevalence among middle-aged and older adults: an analysis of the NHANES 2007-2016

Background: As individuals age, the prevalence of osteoarthritis tends to increase gradually. aKlotho is a hormone renowned for its anti -aging properties. However, the precise role of serum a-Klotho in osteoarthritis is still not fully comprehended. Methods: We conducted a cross-sectional study utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016. Serum a-Klotho levels were measured using an enzyme -linked immunosorbent assay (ELISA). Osteoarthritis was assessed through self -reported questionnaires. Through univariate and multivariate logistic regression analyses, smooth curve fitting, threshold effect analysis, and subgroup analyses, we delved into the potential association between them. Results: The study encompassed a cohort of 10,265 participants. In fully adjusted models of multivariate logistic regression analysis, we identified a negative correlation between serum ln a-Klotho and OA (OR = 0.77, 95% CI: 0.65-0.91, p = 0.003). When stratifying serum a-Klotho levels into tertiles, individuals in the highest tertile exhibited a 26% reduced risk of OA compared to those in the lowest tertile (OR = 0.84, 95% CI: 0.73-0.97, p = 0.014). Subsequent analyses indicated a linearly negative association. In subgroup analyses, we explored the relationship between serum ln a-Klotho and osteoarthritis across diverse populations, revealing the persistence of this association in the majority of subgroups. Conclusion: Serum a-Klotho levels exhibit a significant negative linear correlation with the prevalence of osteoarthritis in middle-aged and elderly populations in the United States. (c) 2024 Elsevier Espa & ntilde;a, S.L.U. and Sociedad Espa & ntilde;ola de Medicina Interna (SEMI). All rights are reserved, including those for text and data mining, AI training, and similar technologies.