T-distributed Stochastic Neighbor Network for unsupervised representation learning

被引:2
|
作者
Wang, Zheng [1 ]
Xie, Jiaxi [1 ]
Nie, Feiping [1 ]
Wang, Rong [1 ]
Jia, Yanyan [2 ]
Liu, Shichang [3 ]
机构
[1] Northwestern Polytech Univ, Sch Artificial Intelligence OPt & Elect iOPEN, Xian 710072, Shaanxi, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, Honghui Hosp, Xian 710004, Shaanxi, Peoples R China
关键词
Unsupervised representation learning; Generic data dimensionality reduction; scRNA-seq clustering; NONLINEAR DIMENSIONALITY REDUCTION; AUTOENCODER;
D O I
10.1016/j.neunet.2024.106520
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Unsupervised representation learning (URL) is still lack of a reasonable operator (e.g. convolution kernel) for exploring meaningful structural information from generic data including vector, image and tabular data. In this paper, we propose a simple end-to-end T-distributed Stochastic Neighbor Network ( TsNet ) for URL with clustering downstream task. Concretely, our TsNet model has three major components: (1) an adaptive connectivity distribution learning module is presented to construct a pairwise graph for preserving the local structure of generic data; (2) a T-distributed stochastic neighbor embedding based loss function is designed to learn a transformation between embeddings and original data, which improves the discrimination of representations; (3) a nonlinear parametric mapping is learned via our TsNet on an unsupervised generalized manner, which can address the " out-of-sample "issue. By combining these components, our method is able to considerably outperform previous related unsupervised learning approaches on visualization and clustering of generic data. A simple deep neural network equipped on our model respectively achieves 74.90%, 76.56% ACC and NMI, which is 8% relative improvement over previous state-of-the-art on real single-cell RNA-sequencing (scRNA-seq) datasets clustering.
引用
收藏
页数:9
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