[1] Univ Toronto, Interdept Div Crit Care Med, Toronto, ON M5S 1A1, Canada
[2] Univ Toronto, Dept Anesthesiol & Pain Med, Toronto, ON M5S 1A1, Canada
[3] St Michaels Hosp, Dept Anesthesia, Toronto, ON M5B 1W8, Canada
[4] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit & Epidemiol Studies Unit CTSU, Oxford, England
[5] Boston Univ, Pulm Ctr, Chobanian & Avedisian Sch Med, Dept Med, Boston, MA USA
[6] St Michaels Hosp, Dept Crit Care Med, 30 Bond St,Room 6-504,Donnelly Wing South, Toronto, ON M5B 1W8, Canada