Characteristics and Outcomes of a Single-Centre Cohort of Adult Congenital Heart Disease Patients Referred for Heart Transplant

被引:2
|
作者
Jayadeva, Pavithra S. [1 ]
Peters, Stacey [1 ]
Tee, Su Ling [2 ]
Burchill, Luke J. [3 ]
Marasco, Silvana F. [2 ]
Grigg, Leeanne [1 ]
Leet, Angeline [2 ]
Mcgif, David
Zentner, Dominica [1 ]
机构
[1] Royal Melbourne Hosp, Dept Cardiol, Melbourne, Vic, Australia
[2] Alfred Hosp, Dept Cardiol & Cardiothorac Surg, Melbourne, Vic, Australia
[3] Mayo Clin, Dept Cardiol, Rochester, MN USA
来源
HEART LUNG AND CIRCULATION | 2024年 / 33卷 / 08期
关键词
Adult congenital heart disease; Heart transplant; Heart failure; MECHANICAL CIRCULATORY SUPPORT; SCIENTIFIC STATEMENT; CHANGING PROFILE; SURVIVAL; REGISTRY; FAILURE; SOCIETY; IMPACT;
D O I
10.1016/j.hlc.2024.02.019
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Adult congenital heart disease (ACHD) services increasingly encounter heart failure (HF) in the ageing ACHD population. Optimal timing of referral for heart transplant (HTx) evaluation in this heterogeneous population is complex and ill-defined. fi ned. We aim to outline the characteristics and outcomes of ACHD patients referred for HTx from a large Australian ACHD centre. Method Retrospective review of ACHD patients referred for HTx from a primary ACHD centre (1992-2021). Database analysis of patient demographics, characteristics, wait-listing, and transplantation outcomes was performed. Results A total of 45 patients (mean age 37 +/- 9.9 +/- 9.9 years old; 69% male) were referred for HTx with a mean followup of 5.9 +/- 6.3 +/- 6.3 years. Of these, 22 of 45 (49%) were listed and transplanted, including one heart-lung transplant. The commonest diagnosis was dextro-transposition of the great arteries (13/45, 29%). Most patients, 33 of 45 (73.3%) had undergone at least one cardiac surgery in childhood. Indications for HTx referral included HF in 34 of 45 (75%), followed by pulmonary hypertension in 7 of 45 (11%). Median transplant wait-list time was 145 days (interquartile range, 112-256). Of the 23 patients not wait- listed, the reasons included clinical stability in 13 of 45 (29%), psychosocial factors in 2 of 45 (4.4%) and prohibitive surgical risk, including multiorgan dysfunction, in 8 of 45 (17.7%). Transplant was of a single organ in most, 21 of 22 (95.5%). Overall mortality was 5 of 22 (22.7%) in those after HTx, and 14 of 23 (60.9%) in those not listed (p=0.0156). Conclusions Increasingly, ACHD patients demonstrate the need for advanced HF treatments. HTx decision-making is complex, and increased mortality is seen in those not wait-listed. Ultimately, the referral of ACHD patients for HTx is underpinned by local decision-making and experience, wait-list times and outcomes.
引用
收藏
页码:1184 / 1192
页数:9
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