3D-Printed Latticed Microneedle Array Patches for Tunable and Versatile Intradermal Delivery

Using high-resolution 3D printing, a novel class of microneedle array patches (MAPs) is introduced, called latticed MAPs (L-MAPs). Unlike most MAPs which are composed of either solid structures or hollow needles, L-MAPs incorporate tapered struts that form hollow cells capable of trapping liquid droplets. The lattice structures can also be coated with traditional viscous coating formulations, enabling both liquid- and solid-state cargo delivery, on a single patch. Here, a library of 43 L-MAP designs is generated and in-silico modeling is used to down-select optimal geometries for further characterization. Compared to traditionally molded and solid-coated MAPs, L-MAPs can load more cargo with fewer needles per patch, enhancing cargo loading and drug delivery capabilities. Further, L-MAP cargo release kinetics into the skin can be tuned based on formulation and needle geometry. In this work, the utility of L-MAPs as a platform is demonstrated for the delivery of small molecules, mRNA lipid nanoparticles, and solid-state ovalbumin protein. In addition, the production of programmable L-MAPs is demonstrated with tunable cargo release profiles, enabled by combining needle geometries on a single patch. 3D-printed latticed microneedle array patches (L-MAPs) have unique geometries capable of delivering both solid-state and liquid-state cargo on a single platform. This technology enables tunable delivery kinetics from the order of minutes to hours for small molecules, proteins, and nucleic acids. The modularity introduced by L-MAPs opens up drug delivery profiles for multiple payloads while enabling ease of administration. image