Formate Dehydrogenase: Recent Developments for NADH and NADPH Recycling in Biocatalysis

被引:0
|
作者
Maier, Artur [1 ]
Mguni, Lindelo M. [1 ]
Ngo, Anna C. R. [1 ]
Tischler, Dirk [1 ]
机构
[1] Ruhr Univ Bochum, Fac Biol & Biotechnol Microbial Biotechnol, Univ Str 150, D-44780 Bochum, Germany
关键词
oxidoreductase; biocatalysis; enzyme cascade; protein engineering; biotransformation; COFACTOR SPECIFICITY; CATALYTIC-PROPERTIES; ESCHERICHIA-COLI; CANDIDA-BOIDINII; CLONING; FUSION; GENE; PURIFICATION; EXPRESSION; PROTEIN;
D O I
10.1002/cctc.202401021
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Formate dehydrogenases (FDHs) catalyze the oxidation of formate to CO2 while reducing NAD(P)+ to NAD(P)H and are classified into two main classes: metal-dependent (Mo- or W-containing) and metal-independent FDHs. The latter are oxygen-tolerant and relevant as a cofactor regeneration system for various bioprocesses and gained more and more attention due to their ability to catalyze the reverse CO2 reduction. This review gives an overview of metal-independent FDHs, the recent advances made in this field, and their relevance for future applications in biocatalysis. This includes the exploitation of novel FDHs which have altered co-substrate specificity as well as enzyme engineering approaches to improve process stability and general performance. Formate dehydrogenases (FDHs) are widely utilized to drive various biocatalysts for the production of valuable compounds. Recent advancements in enzyme engineering have enhanced the functionality of metal-independent FDHs, increasing their applicability and suitability for specific bioprocesses. This review highlights the latest progress in FDH research, with a particular focus on structural insights, engineering progress, and applications in bioprocesses. image
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页数:16
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