Asymmetric Synthesis of Chiral Cyclopropanes from Vinyl Sulfoxonium Ylides Catalyzed by a Chiral-at-Metal Rh(III) Complex

被引：2
|
作者：
Xie, Xiaoting [1 ]
Zhao, Zhifei [1 ]
Wang, Jun [2 ]
Li, Shi-Wu [1 ]
机构：
[1] Shihezi Univ, Sch Chem & Chem Engn, State Key Lab Incubat Base Green Proc Chem Engn, Shihezi 832003, Xinjiang, Peoples R China
[2] Nanyang Inst Technol, Zhang Zhongjing Sch Chinese Med, Nanyang 473004, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 38期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1021/acs.orglett.4c03051
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A chiral-at-metal Rh(III) complex-mediated [2+1] cyclization of vinyl sulfoxonium ylides with alpha,beta-unsaturated 2,2-acylimidazoles has been demonstrated for the first time. This work provides a practical approach for assembling 1,2,3-trisubstituted chiral cyclopropane with alkyl structural units, which had advantages such as a wide range of substrates, good functional group tolerance, and mild reaction conditions. In addition, further amplification experiments and transformation of cycloaddition products were carried out to highlight the practicality of the method.
引用
收藏
页码：8144 / 8148
页数：5
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