Navigating the Postoperative Management of Remifentanil-Induced Hyperalgesia: A Case Report

被引：0

作者：

Smith, Nathan T. ^{[1
]}

Fernholz, Ryan ^{[2
]}

Juresic, Sanny ^{[3
]}

机构：

[1] Mayo Clin, Pharm, PharmD, Rochester, NY 55905 USA

[2] Mayo Fdn Med Educ & Res, Pharm, PharmD, Rochester, NY USA

[3] Dept Pharm, Mayo Clin, PharmD, Rochester, NY USA

来源：

JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY | 2024年

关键词：

Opioid induced hyperalgesia; remifentanil induced hyperalgesia; hyperalgesia; hyperalgesia treatment; opioid; MAJOR SURGERY; PREVENTION; KETAMINE; ADULTS; MECHANISMS; ANALGESIA; TOLERANCE;

D O I：

10.1080/15360288.2024.2400901

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Opioid induced hyperalgesia in the postoperative setting presents a significant challenge for clinicians managing postoperative pain in opioid tolerant patients. Remifentanil is a fentanyl analog frequently utilized in anesthesia for its favorable pharmacokinetic profile. However, as described in the case report, it may also increase the risk of postoperative hyperalgesia. Management of postoperative pain in the setting of hyperalgesia should be approached in a stepwise fashion, emphasizing therapy options with analgesic effects achieved outside of the opioidergic system while maintaining a neutral opioid balance.

引用

页数：6

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