Repurposing Drugs for Cancer Prevention

被引：0
|
作者：
Choradia, Nirmal [1 ]
Szabo, Eva [2 ]
机构：
[1] NCI, NIH, Ctr Canc Res, Med Oncol Serv, Bethesda, MD USA
[2] NCI, Div Canc Prevent, Lung & Upper Aerodigest Canc Res Grp, 9609 Med Ctr Dr,Rm 5E-102, Bethesda, MD 20892 USA
来源：
CANCER JOURNAL | 2024年 / 30卷 / 05期
关键词：
Cancer prevention; chronic diseases; repurposing; SURGICAL ADJUVANT BREAST; PROSTATE-CANCER; CLONAL HEMATOPOIESIS; BOWEL PROJECT; TRIAL; RISK; ASPIRIN; OBESITY; MORTALITY; METFORMIN;
D O I：
10.1097/PPO.0000000000000746
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The development of agents for cancer prevention is a lengthy process requiring a delicate balance between the safety and tolerability of potential interventions and effectiveness in preventing future cancer. Individuals at risk for a specific cancer are frequently at risk for multiple types of cancer as well as other chronic diseases, especially ones associated with aging. Shared environmental exposures, genetic predisposition, metabolic factors, and commonalities in pathogenesis suggest opportunities for combined targeting of cancer and other chronic diseases. Examples discussed here include mechanisms shared between various cancers and obesity, diabetes, and cardiovascular disease.
引用
收藏
页码：345 / 351
页数：7
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