Benzothiazole-Directed Enantioselective Borylation of Secondary Benzylic C-H Bonds Using Iridium Catalysis

被引：2

作者：

Xie, Liang-Jun ^{[1
,2
]}

Chen, Lili ^{[1
,3
]}

Xu, Senmiao ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Lanzhou Inst Chem Phys, Suzhou Res Inst, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2024年 / 56卷 / 17期

关键词：

asymmetric catalysis; borylation; chiral bidentate boryl ligands; C-H activation; synthetic methods; C(SP(3))-H BONDS; FUNCTIONALIZATION;

D O I：

10.1055/a-2335-8677

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reported here is the iridium-catalyzed regio- and enantio-selective secondary benzylic C-H borylation using benzothiazole as the directing group. Various monosubstituted 2-arylalkylbenzo[d]thiazole were well-tolerated, affording the corresponding products in moderate to good yields with good enantioselectivity. The C-B bond in one borylated product could undergo stereospecific transformations to form aseries of C-C and C-heteroatom bonds.

引用

页码：2638 / 2647

页数：10

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